FOXD4L4
Forkhead box protein D4-like 4
Also known as: bA460E7.2, FOXD4L2, FX4L4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WXT5
- Gene
- FOXD4L4
- Ensembl
- ENSG00000184659
- Chromosome
- 9
- Canonical length
- 416 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
416 residues, UniProt reviewed canonical sequence.
>Q8WXT5|FOXD4L4
1 MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF LEQSLQPGLQ
61 VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
121 ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
181 YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP
241 APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSARVYAG APKKAEGADL ATPAPFPCCS
301 PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ
361 ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP PRARCWAGTC RPRRRCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FOXD4L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 0.5 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 0.5 nTPM
- basal ganglia: 0.3 nTPM
- cerebral cortex: 0.3 nTPM
- hippocampal formation: 0.3 nTPM
- hypothalamus: 0.2 nTPM
- salivary gland: 0.2 nTPM
Single-cell type
- cardiomyocytes: 0.3 nCPM
- proximal tubule cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 4.8 nTPM
- pons: 3.5 nTPM
- hippocampal formation: 3.4 nTPM
- medulla oblongata: 2.8 nTPM
- basal ganglia: 2.3 nTPM
- cerebellum: 1.9 nTPM
OntologyGO
Biological processes
- anatomical structure morphogenesis
- cell differentiation
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FOXD4L4 as an antibody target. Whether an autoantibody or antibody against FOXD4L4 could matter depends on whether native FOXD4L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FOXD4L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FOXD4L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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