SPIC
Transcription factor Spi-C
Also known as: MGC40611, SPI-C, SPIC_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N5J4
- Gene
- SPIC
- Ensembl
- ENSG00000166211
- Chromosome
- 12
- Canonical length
- 248 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]
Canonical amino-acid sequenceUniProt
248 residues, UniProt reviewed canonical sequence.
>Q8N5J4|SPIC
1 MTCVEQDKLG QAFEDAFEVL RQHSTGDLQY SPDYRNYLAL INHRPHVKGN SSCYGVLPTE
61 EPVYNWRTVI NSAADFYFEG NIHQSLQNIT ENQLVQPTLL QQKGGKGRKK LRLFEYLHES
121 LYNPEMASCI QWVDKTKGIF QFVSKNKEKL AELWGKRKGN RKTMTYQKMA RALRNYGRSG
181 EITKIRRKLT YQFSEAILQR LSPSYFLGKE IFYSQCVQPD QEYLSLNNWN ANYNYTYANY
241 HELNHHDCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPIC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- spleen: 29 nTPM
- lymph node: 3 nTPM
- tonsil: 2.4 nTPM
- liver: 2 nTPM
- thymus: 1.1 nTPM
- appendix: 0.6 nTPM
Single-cell type
- kupffer cells: 62 nCPM
- macrophages: 15 nCPM
- platelets: 8.4 nCPM
- monocytes: 1.3 nCPM
- neutrophil progenitors: 1.2 nCPM
- respiratory secretory cells: 1.1 nCPM
Immune cell
- intermediate monocyte: 1.1 nTPM
- non-classical monocyte: 0.3 nTPM
- naive CD8 T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebral cortex: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.62
- gnomAD pLI
- 0.31
- gnomAD missense Z
- 0.3
- DepMap mean gene effect
- -0.29
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPIC as an antibody target. Whether an autoantibody or antibody against SPIC could matter depends on whether native SPIC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPIC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPIC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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