FOXJ3

Protein identityUniProt · HPA

UniProt accession

Q9UPW0

Gene

FOXJ3

Ensembl

ENSG00000198815

Chromosome

1

Canonical length

622 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nuclear speckles,Vesicles

OverviewNCBI Gene

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

622 residues, UniProt reviewed canonical sequence.

>Q9UPW0|FOXJ3
     1  MGLYGQACPS VTSLRMTSEL ESSLTSMDWL PQLTMRAAIQ KSDATQNAHG TGISKKNALL
    61  DPNTTLDQEE VQQHKDGKPP YSYASLITFA INSSPKKKMT LSEIYQWICD NFPYYREAGS
   121  GWKNSIRHNL SLNKCFLKVP RSKDDPGKGS YWAIDTNPKE DVLPTRPKKR ARSVERASTP
   181  YSIDSDSLGM ECIISGSASP TLAINTVTNK VTLYNTDQDG SDSPRSSLNN SLSDQSLASV
   241  NLNSVGSVHS YTPVTSHPES VSQSLTPQQQ PQYNLPERDK QLLFSEYNFE DLSASFRSLY
   301  KSVFEQSLSQ QGLMNIPSES SQQSHTSCTY QHSPSSTVST HPHSNQSSLS NSHGSGLNTT
   361  GSNSVAQVSL SHPQMHTQPS PHPPHRPHGL PQHPQRSPHP APHPQQHSQL QSPHPQHPSP
   421  HQHIQHHPNH QHQTLTHQAP PPPQQVSCNS GVSNDWYATL DMLKESCRIA SSVNWSDVDL
   481  SQFQGLMESM RQADLKNWSL DQVQFADLCS SLNQFFTQTG LIHSQSNVQQ NVCHGAMHPT
   541  KPSQHIGTGN LYIDSRQNLP PSVMPPPGYP HIPQALSTPG TTMAGHHRAM NQQHMMPSQA
   601  FQMRRSLPPD DIQDDFDWDS IV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXJ3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.58

Highest tissue expression

40 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.27

gnomAD pLI

1

gnomAD missense Z

1.31

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• male meiosis I
• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II
• spermatogenesis

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Fork head domain
• Fork head domain conserved site1
• Fork head domain conserved site 2
• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• Forkhead box protein J2/3-like
• Forkhead domain

KeywordsUniProt

• Differentiation
• DNA-binding
• Meiosis
• Nucleus
• Phosphoprotein
• Spermatogenesis
• Transcription
• Transcription regulation