Seroatlas · Human Serome Atlas

POLR3C

DNA-directed RNA polymerase III subunit RPC3

Also known as: C82, RPC3, RPC3_HUMAN, RPC62

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BUI4
Gene
POLR3C
Ensembl
ENSG00000186141
Chromosome
1
Canonical length
534 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables single-stranded DNA binding activity. Involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

534 residues, UniProt reviewed canonical sequence.

>Q9BUI4|POLR3C
     1  MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTGTSLDQV KKALCVLVQH
    61  NLVSYQVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYS DTGELIVEEL LLNGKLTMSA
   121  VVKKVADRLT ETMEDGKTMD YAEVSNTFVR LADTHFVQRC PSVPTTENSD PGPPPPAPTL
   181  VINEKDMYLV PKLSLIGKGK RRRSSDEDAA GEPKAKRPKY TTDNKEPIPD DGIYWQANLD
   241  RFHQHFRDQA IVSAVANRMD QTSSEIVRTM LRMSEITTSS SAPFTQPLSS NEIFRSLPVG
   301  YNISKQVLDQ YLTLLADDPL EFVGKSGDSG GGMYVINLHK ALASLATATL ESVVQERFGS
   361  RCARIFRLVL QKKHIEQKQV EDFAMIPAKE AKDMLYKMLS ENFMSLQEIP KTPDHAPSRT
   421  FYLYTVNILS AARMLLHRCY KSIANLIERR QFETKENKRL LEKSQRVEAI IASMQATGAE
   481  EAQLQEIEEM ITAPERQQLE TLKRNVNKLD ASEIQVDETI FLLESYIECT MKRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLR3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • testis: 15 nTPM
  • ovary: 13 nTPM
  • adipose tissue: 12 nTPM
  • tonsil: 12 nTPM
  • blood vessel: 12 nTPM
  • thymus: 12 nTPM

Single-cell type

  • late spermatids: 832 nCPM
  • early spermatids: 387 nCPM
  • late primary spermatocytes: 119 nCPM
  • oocytes: 69 nCPM
  • mast cells: 46 nCPM
  • undifferentiated spermatogonia: 45 nCPM

Immune cell

  • basophil: 47 nTPM
  • intermediate monocyte: 35 nTPM
  • myeloid DC: 32 nTPM
  • eosinophil: 30 nTPM
  • NK-cell: 30 nTPM
  • plasmacytoid DC: 29 nTPM

Brain region

  • cerebellum: 9.2 nTPM
  • pons: 6.1 nTPM
  • cerebral cortex: 5.9 nTPM
  • white matter: 5.9 nTPM
  • thalamus: 5.7 nTPM
  • amygdala: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
1.02
DepMap mean gene effect
-1.18
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Winged helix-like DNA-binding domain superfamily
  • RNA polymerase III Rpc82, C -terminal
  • RNA polymerase III subunit RPC82-related, helix-turn-helix
  • DNA-directed RNA polymerase III subunit RPC3
  • DNA-directed RNA polymerase III subunit RPC3, winged-helix domain
  • RNA polymerase III subunit RPC82
  • RNA polymerase III subunit RPC82 helix-turn-helix domain
  • DNA-directed RNA polymerase III subunit RPC3, helical hairpin domain
  • POLR3C, C-terminal winged-helix domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLR3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLR3C as an antibody target. Whether an autoantibody or antibody against POLR3C could matter depends on whether native POLR3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLR3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLR3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POLR3C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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