Seroatlas · Human Serome Atlas

FOXK2

Forkhead box protein K2

Also known as: FOXK2_HUMAN, ILF, ILF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q01167
Gene
FOXK2
Ensembl
ENSG00000141568
Chromosome
17
Canonical length
660 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Vesicles,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

660 residues, UniProt reviewed canonical sequence.

>Q01167|FOXK2
     1  MAAAAAALSG AGTPPAGGGA GGGGAGGGGS PPGGWAVARL EGREFEYLMK KRSVTIGRNS
    61  SQGSVDVSMG HSSFISRRHL EIFTPPGGGG HGGAAPELPP AQPRPDAGGD FYLRCLGKNG
   121  VFVDGVFQRR GAPPLQLPRV CTFRFPSTNI KITFTALSSE KREKQEASES PVKAVQPHIS
   181  PLTINIPDTM AHLISPLPSP TGTISAANSC PSSPRGAGSS GYKVGRVMPS DLNLMADNSQ
   241  PENEKEASGG DSPKDDSKPP YSYAQLIVQA ITMAPDKQLT LNGIYTHITK NYPYYRTADK
   301  GWQNSIRHNL SLNRYFIKVP RSQEEPGKGS FWRIDPASES KLIEQAFRKR RPRGVPCFRT
   361  PLGPLSSRSA PASPNHAGVL SAHSSGAQTP ESLSREGSPA PLEPEPGAAQ PKLAVIQEAR
   421  FAQSAPGSPL SSQPVLITVQ RQLPQAIKPV TYTVATPVTT STSQPPVVQT VHVVHQIPAV
   481  SVTSVAGLAP ANTYTVSGQA VVTPAAVLAP PKAEAQENGD HREVKVKVEP IPAIGHATLG
   541  TASRIIQTAQ TTPVQTVTIV QQAPLGQHQL PIKTVTQNGT HVASVPTAVH GQVNNAAASP
   601  LHMLATHASA SASLPTKRHN GDQPEQPELK RIKTEDGEGI VIALSVDTPP AAVREKGVQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 40 nTPM
  • tongue: 27 nTPM
  • testis: 26 nTPM
  • adrenal gland: 25 nTPM
  • blood vessel: 19 nTPM
  • esophagus: 19 nTPM

Single-cell type

  • epicardial cells: 357 nCPM
  • mast cells: 289 nCPM
  • monocytes: 237 nCPM
  • myonuclei: 207 nCPM
  • lactotrophs: 202 nCPM
  • somatotrophs: 196 nCPM

Immune cell

  • plasmacytoid DC: 2 nTPM
  • NK-cell: 1.6 nTPM
  • basophil: 1.5 nTPM
  • memory B-cell: 1.5 nTPM
  • gdT-cell: 1.4 nTPM
  • memory CD8 T-cell: 1.4 nTPM

Brain region

  • cerebral cortex: 58 nTPM
  • cerebellum: 54 nTPM
  • white matter: 49 nTPM
  • hippocampal formation: 47 nTPM
  • amygdala: 46 nTPM
  • hypothalamus: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.03
gnomAD missense Z
0.4
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FOXK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXK2 as an antibody target. Whether an autoantibody or antibody against FOXK2 could matter depends on whether native FOXK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOXK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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