Seroatlas · Human Serome Atlas

IRF4

Interferon regulatory factor 4

Also known as: IRF4_HUMAN, LSIRF, MUM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15306
Gene
IRF4
Ensembl
ENSG00000137265
Chromosome
6
Canonical length
451 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>Q15306|IRF4
     1  MNLEGGGRGG EFGMSAVSCG NGKLRQWLID QIDSGKYPGL VWENEEKSIF RIPWKHAGKQ
    61  DYNREEDAAL FKAWALFKGK FREGIDKPDP PTWKTRLRCA LNKSNDFEEL VERSQLDISD
   121  PYKVYRIVPE GAKKGAKQLT LEDPQMSMSH PYTMTTPYPS LPAQQVHNYM MPPLDRSWRD
   181  YVPDQPHPEI PYQCPMTFGP RGHHWQGPAC ENGCQVTGTF YACAPPESQA PGVPTEPSIR
   241  SAEALAFSDC RLHICLYYRE ILVKELTTSS PEGCRISHGH TYDASNLDQV LFPYPEDNGQ
   301  RKNIEKLLSH LERGVVLWMA PDGLYAKRLC QSRIYWDGPL ALCNDRPNKL ERDQTCKLFD
   361  TQQFLSELQA FAHHGRSLPR FQVTLCFGEE FPDPQRQRKL ITAHVEPLLA RQLYYFAQQN
   421  SGHFLRGYDL PEHISNPEDY HRSIRHSSIQ E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 39 nTPM
  • tonsil: 25 nTPM
  • lymph node: 22 nTPM
  • appendix: 18 nTPM
  • spleen: 17 nTPM
  • cervix: 11 nTPM

Single-cell type

  • pdcs: 596 nCPM
  • plasma cells: 361 nCPM
  • melanocytes: 167 nCPM
  • cdc: 124 nCPM
  • b-cells: 107 nCPM
  • innate lymphoid cells: 96 nCPM

Immune cell

  • plasmacytoid DC: 13 nTPM
  • naive B-cell: 11 nTPM
  • myeloid DC: 11 nTPM
  • memory B-cell: 11 nTPM
  • T-reg: 5.9 nTPM
  • classical monocyte: 2 nTPM

Brain region

  • white matter: 1.9 nTPM
  • cerebral cortex: 1.8 nTPM
  • medulla oblongata: 1.7 nTPM
  • choroid plexus: 1.6 nTPM
  • midbrain: 1.5 nTPM
  • pons: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IRF4.

Disease | AllUniProt

Conditions IRF4 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 350 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Immunodeficiency 131

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.86
gnomAD missense Z
2.85
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IRF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRF4 as an antibody target. Whether an autoantibody or antibody against IRF4 could matter depends on whether native IRF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IRF4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...