DEPDC7
DEP domain-containing protein 7
Also known as: DEPD7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96QD5
- Gene
- DEPDC7
- Ensembl
- ENSG00000121690
- Chromosome
- 11
- Canonical length
- 511 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Cytosol
OverviewNCBI Gene
Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
511 residues, UniProt reviewed canonical sequence.
>Q96QD5|DEPDC7
1 MATVQEKAAA LNLSALHSPA HRPPGFSVAQ KPFGATYVWS SIINTLQTQV EVKKRRHRLK
61 RHNDCFVGSE AVDVIFSHLI QNKYFGDVDI PRAKVVRVCQ ALMDYKVFEA VPTKVFGKDK
121 KPTFEDSSCS LYRFTTIPNQ DSQLGKENKL YSPARYADAL FKSSDIRSAS LEDLWENLSL
181 KPANSPHVNI SATLSPQVIN EVWQEETIGR LLQLVDLPLL DSLLKQQEAV PKIPQPKRQS
241 TMVNSSNYLD RGILKAYSDS QEDEWLSAAI DCLEYLPDQM VVEISRSFPE QPDRTDLVKE
301 LLFDAIGRYY SSREPLLNHL SDVHNGIAEL LVNGKTEIAL EATQLLLKLL DFQNREEFRR
361 LLYFMAVAAN PSEFKLQKES DNRMVVKRIF SKAIVDNKNL SKGKTDLLVL FLMDHQKDVF
421 KIPGTLHKIV SVKLMAIQNG RDPNRDAGYI YCQRIDQRDY SNNTEKTTKD ELLNLLKTLD
481 EDSKLSAKEK KKLLGQFYKC HPDIFIEHFG DLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DEPDC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 69 nTPM
Expression across tissuesHPA
Tissue
- liver: 69 nTPM
- small intestine: 27 nTPM
- testis: 26 nTPM
- duodenum: 23 nTPM
- kidney: 18 nTPM
- skin: 5.6 nTPM
Single-cell type
- early spermatids: 180 nCPM
- late primary spermatocytes: 151 nCPM
- extravillous trophoblasts: 77 nCPM
- tuft cells: 58 nCPM
- enterocytes: 45 nCPM
- hepatocytes: 41 nCPM
Immune cell
- eosinophil: 6.7 nTPM
- basophil: 4.1 nTPM
- myeloid DC: 3.2 nTPM
- NK-cell: 2.4 nTPM
- naive CD8 T-cell: 2.1 nTPM
- naive CD4 T-cell: 1.9 nTPM
Brain region
- white matter: 7.3 nTPM
- medulla oblongata: 3.8 nTPM
- basal ganglia: 3.6 nTPM
- cerebellum: 3 nTPM
- pons: 3 nTPM
- cerebral cortex: 2.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.1
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.96
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DEPDC7 as an antibody target. Whether an autoantibody or antibody against DEPDC7 could matter depends on whether native DEPDC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DEPDC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DEPDC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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