GTF2E2

Protein identityUniProt · HPA

UniProt accession

P29084

Gene

GTF2E2

Ensembl

ENSG00000197265

Chromosome

8

Canonical length

291 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>P29084|GTF2E2
     1  MDPSLLRERE LFKKRALSTP VVEKRSASSE SSSSSSKKKK TKVEHGGSSG SKQNSDHSNG
    61  SFNLKALSGS SGYKFGVLAK IVNYMKTRHQ RGDTHPLTLD EILDETQHLD IGLKQKQWLM
   121  TEALVNNPKI EVIDGKYAFK PKYNVRDKKA LLRLLDQHDQ RGLGGILLED IEEALPNSQK
   181  AVKALGDQIL FVNRPDKKKI LFFNDKSCQF SVDEEFQKLW RSVTVDSMDE EKIEEYLKRQ
   241  GISSMQESGP KKVAPIQRRK KPASQKKRRF KTHNEHLAGV LKDYSDITSS K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTF2E2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

49 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GTF2E2.

Disease | AllUniProt

Conditions GTF2E2 is implicated in, by any mechanism.

• Trichothiodystrophy 6, non-photosensitive (TTD6) MIM:616943

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 190 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Trichothiodystrophy 6, nonphotosensitive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.61

gnomAD pLI

0.04

gnomAD missense Z

0.9

DepMap mean gene effect

-1.39

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• transcription by RNA polymerase II
• transcription initiation at RNA polymerase II promoter

Molecular functions

• DNA binding
• RNA binding
• RNA polymerase II general transcription initiation factor activity

Cellular components

• cytosol
• nucleoplasm
• transcription factor TFIID complex
• transcription factor TFIIE complex

Protein domainsUniProt · Pfam · InterPro

• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• Transcription factor TFIIE beta subunit, DNA-binding domain
• Transcription initiation factor TFIIE, beta subunit
• TFA2, Winged helix domain 2
• TFIIE beta subunit core domain
• TFA2 Winged helix domain 2

KeywordsUniProt

• Acetylation
• DNA-binding
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of GTF2E2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATF7IP
• SND1
• SUPT16H
• GTF2E1
• MCC