Seroatlas · Human Serome Atlas

DVL3

Segment polarity protein dishevelled homolog DVL-3

Also known as: DVL3_HUMAN, KIAA0208

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92997
Gene
DVL3
Ensembl
ENSG00000161202
Chromosome
3
Canonical length
716 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Plasma membrane,Intermediate filaments,Midbody ring,Centrosome,Basal body

OverviewNCBI Gene

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

716 residues, UniProt reviewed canonical sequence.

>Q92997|DVL3
     1  MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI
    61  SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP PPMERTGGIG DSRPPSFHPH
   121  AGGGSQENLD NDTETDSLVS AQRERPRRRD GPEHATRLNG TAKGERRREP GGYDSSSTLM
   181  SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD
   241  STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL
   301  QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS EPIRPIDPAA
   361  WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER LDDFHLSIHS DMAAIVKAMA
   421  SPESGLEVRD RMWLKITIPN AFIGSDVVDW LYHNVEGFTD RREARKYASN LLKAGFIRHT
   481  VNKITFSEQC YYIFGDLCGN MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY
   541  PPPPHPYNPH PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG
   601  SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL ASSLRSHHTH PSYGPPGVPP
   661  LYGPPMLMMP PPPAAMGPPG APPGRDLASV PPELTASRQS FRMAMGNPSE FFVDVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DVL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • colon: 44 nTPM
  • endometrium: 40 nTPM
  • ovary: 40 nTPM
  • blood vessel: 37 nTPM
  • cervix: 37 nTPM
  • placenta: 36 nTPM

Single-cell type

  • late spermatids: 82 nCPM
  • syncytiotrophoblasts: 60 nCPM
  • smooth muscle cells: 47 nCPM
  • distal convoluted tubule cells: 47 nCPM
  • foveolar cells: 47 nCPM
  • hepatic stellate cells: 45 nCPM

Immune cell

  • eosinophil: 1.3 nTPM
  • intermediate monocyte: 1 nTPM
  • neutrophil: 0.9 nTPM
  • MAIT T-cell: 0.8 nTPM
  • plasmacytoid DC: 0.8 nTPM
  • memory B-cell: 0.7 nTPM

Brain region

  • cerebral cortex: 32 nTPM
  • medulla oblongata: 28 nTPM
  • white matter: 26 nTPM
  • cerebellum: 26 nTPM
  • basal ganglia: 26 nTPM
  • midbrain: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DVL3.

Disease | AllUniProt

Conditions DVL3 is implicated in, by any mechanism.

  • Robinow syndrome, autosomal dominant 3 (DRS3) MIM:616894

Disease | GeneticClinVar

20 pathogenic / likely-pathogenic of 469 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.39
gnomAD missense Z
2.32
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 19% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DVL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DVL3 as an antibody target. Whether an autoantibody or antibody against DVL3 could matter depends on whether native DVL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DVL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DVL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DVL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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