Seroatlas · Human Serome Atlas

FOXD4L5

Forkhead box protein D4-like 5

Also known as: bA15J10.2, FX4L5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VV16
Gene: FOXD4L5
Ensembl: ENSG00000204779
Chromosome: 9
Canonical length: 416 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q5VV16|FOXD4L5
     1  MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF LEQSLQPGLQ
    61  VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
   121  ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
   181  YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP
   241  APPQPVPGAY PNTAPGRCPY ALLHPHPLRY LLLSAPVYAG APKKAEGADL ATPAPFPCCS
   301  PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ
   361  ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP PRARCWAGTC RPRRRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXD4L5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

retina: 0.6 nTPM
cerebellum: 0.3 nTPM
cerebral cortex: 0.3 nTPM
skin: 0.3 nTPM
adrenal gland: 0.2 nTPM
basal ganglia: 0.2 nTPM

Single-cell type

cardiomyocytes: 0.2 nCPM
renal connecting tubule cells: 0.2 nCPM
corticotrophs: 0.1 nCPM
distal convoluted tubule cells: 0.1 nCPM
loop of henle epithelial cells: 0.1 nCPM
oligodendrocyte progenitor cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 5.7 nTPM
hippocampal formation: 5.2 nTPM
cerebellum: 4.8 nTPM
pons: 4.4 nTPM
white matter: 4.3 nTPM
basal ganglia: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.28
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXD4L5 as an antibody target. Whether an autoantibody or antibody against FOXD4L5 could matter depends on whether native FOXD4L5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXD4L5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXD4L5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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