IRF9

Protein identityUniProt · HPA

UniProt accession

Q00978

Gene

IRF9

Ensembl

ENSG00000213928

Chromosome

14

Canonical length

393 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q00978|IRF9
     1  MASGRARCTR KLRNWVVEQV ESGQFPGVCW DDTAKTMFRI PWKHAGKQDF REDQDAAFFK
    61  AWAIFKGKYK EGDTGGPAVW KTRLRCALNK SSEFKEVPER GRMDVAEPYK VYQLLPPGIV
   121  SGQPGTQKVP SKRQHSSVSS ERKEEEDAMQ NCTLSPSVLQ DSLNNEEEGA SGGAVHSDIG
   181  SSSSSSSPEP QEVTDTTEAP FQGDQRSLEF LLPPEPDYSL LLTFIYNGRV VGEAQVQSLD
   241  CRLVAEPSGS ESSMEQVLFP KPGPLEPTQR LLSQLERGIL VASNPRGLFV QRLCPIPISW
   301  NAPQAPPGPG PHLLPSNECV ELFRTAYFCR DLVRYFQGLG PPPKFQVTLN FWEESHGSSH
   361  TPQNLITVKM EQAFARYLLE QTPEQQAAIL SLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRF9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

58 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IRF9.

Disease | AllUniProt

Conditions IRF9 is implicated in, by any mechanism.

• Immunodeficiency 65 (IMD65) MIM:618648

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0.61

gnomAD missense Z

1.57

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor signaling pathway
• defense response to virus
• immune system process
• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II
• transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• cytoplasm
• cytosol
• ISGF3 complex
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Interferon regulatory factor, DNA-binding domain
• SMAD/FHA domain superfamily
• SMAD-like domain superfamily
• Interferon regulatory factor-3
• Interferon regulatory factor, conserved site
• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• Interferon regulatory factor transcription factor
• Interferon-regulatory factor 3

KeywordsUniProt

• Activator
• Antiviral defense
• Cytoplasm
• DNA-binding
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of IRF9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• STAT2