Seroatlas · Human Serome Atlas

H1-9P

Putative histone H1.9

Also known as: HILS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60008
Gene: H1-9P
Canonical length: 231 aa

OverviewNCBI Gene

No narrative summary is available for H1-9P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

231 residues, UniProt reviewed canonical sequence.

>P60008|H1-9P
     1  MLHASTIWHL RSTPPRRKQW GHCDPHRILV ASEVTTEITS PTPAPRAQVC GGQPWVTVLD
    61  PLSGHTGREA ERHFATVSIS AVELKYCHGW RPAGQRVPSK TATGQRTCAK PCQKPSTSKV
   121  ILRAVADKGT CKYVSLATLK KAVSTTGYDM ARNAYHFKRV LKGLVDKGSA GSFTLGKKQA
   181  SKSKLKVKRQ RQQRWRSGQR PFGQHRSLLG SKQGHKRLIK GVRRVAKCHC N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H1-9P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H1-9P as an antibody target. Whether an autoantibody or antibody against H1-9P could matter depends on whether native H1-9P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H1-9P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H1-9P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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