Seroatlas · Human Serome Atlas

FOXB2

Forkhead box protein B2

Also known as: bA159H20.4, FOXB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VYV0
Gene: FOXB2
Ensembl: ENSG00000204612
Chromosome: 9
Canonical length: 432 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q5VYV0|FOXB2
     1  MPRPGKSSYS DQKPPYSYIS LTAMAIQHSA EKMLPLSDIY KFIMERFPYY REHTQRWQNS
    61  LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PDCGDMFENG SFLRRRKRFK VLRADHTHLH
   121  AGSTKSAPGA GPGGHLHPHH HHHPHHHHHH HAAAHHHHHH HPPQPPPPPP PPPPHMVHYF
   181  HQQPPTAPQP PPHLPSQPPQ QPPQQSQPQQ PSHPGKMQEA AAVAAAAAAA AAAAVGSVGR
   241  LSQFPPYGLG SAAAAAAAAA ASTSGFKHPF AIENIIGRDY KGVLQAGGLP LASVMHHLGY
   301  PVPGQLGNVV SSVWPHVGVM DSVAAAAAAA AAAGVPVGPE YGAFGVPVKS LCHSASQSLP
   361  AMPVPIKPTP ALPPVSALQP GLTVPAASQQ PPAPSTVCSA AAASPVASLL EPTAPTSAES
   421  KGGSLHSVLV HS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early primary spermatocytes: 0.1 nCPM
fallopian tube ciliated cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 13 nTPM
cerebral cortex: 3.1 nTPM
medulla oblongata: 2.2 nTPM
pons: 1.4 nTPM
hippocampal formation: 0.9 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXB2 as an antibody target. Whether an autoantibody or antibody against FOXB2 could matter depends on whether native FOXB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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