Seroatlas · Human Serome Atlas

FOXF1

Forkhead box protein F1

Also known as: FKHL5, FOXF1_HUMAN, FREAC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12946
Gene
FOXF1
Ensembl
ENSG00000103241
Chromosome
16
Canonical length
379 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

379 residues, UniProt reviewed canonical sequence.

>Q12946|FOXF1
     1  MSSAPEKQQP PHGGGGGGGG GGGAAMDPAS SGPSKAKKTN AGIRRPEKPP YSYIALIVMA
    61  IQSSPTKRLT LSEIYQFLQS RFPFFRGSYQ GWKNSVRHNL SLNECFIKLP KGLGRPGKGH
   121  YWTIDPASEF MFEEGSFRRR PRGFRRKCQA LKPMYSMMNG LGFNHLPDTY GFQGSAGGLS
   181  CPPNSLALEG GLGMMNGHLP GNVDGMALPS HSVPHLPSNG GHSYMGGCGG AAAGEYPHHD
   241  SSVPASPLLP TGAGGVMEPH AVYSGSAAAW PPSASAALNS GASYIKQQPL SPCNPAANPL
   301  SGSLSTHSLE QPYLHQNSHN APAELQGIPR YHSQSPSMCD RKEFVFSFNA MASSSMHSAG
   361  GGSYYHQQVT YQDIKPCVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • colon: 58 nTPM
  • urinary bladder: 48 nTPM
  • lung: 32 nTPM
  • prostate: 25 nTPM
  • stomach: 25 nTPM
  • placenta: 22 nTPM

Single-cell type

  • fibroblasts: 45 nCPM
  • hepatic stellate cells: 39 nCPM
  • smooth muscle cells: 33 nCPM
  • pericytes: 31 nCPM
  • vascular smooth muscle cells: 29 nCPM
  • vascular endothelial cells: 26 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 8.9 nTPM
  • pons: 7.2 nTPM
  • amygdala: 7 nTPM
  • medulla oblongata: 6.7 nTPM
  • midbrain: 5.6 nTPM
  • basal ganglia: 5.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FOXF1.

Disease | AllUniProt

Conditions FOXF1 is implicated in, by any mechanism.

  • Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) MIM:265380

Disease | GeneticClinVar

66 pathogenic / likely-pathogenic of 245 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.96
gnomAD missense Z
1.09
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXF1 as an antibody target. Whether an autoantibody or antibody against FOXF1 could matter depends on whether native FOXF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOXF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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