Seroatlas · Human Serome Atlas

RIOK2

Serine/threonine-protein kinase RIO2

Also known as: FLJ11159, RIOK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVS4
Gene: RIOK2
Ensembl: ENSG00000058729
Chromosome: 5
Canonical length: 552 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable protein kinase activity. Involved in several processes, including positive regulation of rRNA processing; positive regulation of ribosomal small subunit export from nucleus; and regulation of mitotic metaphase/anaphase transition. Located in cytoplasm. Part of preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

552 residues, UniProt reviewed canonical sequence.

>Q9BVS4|RIOK2
     1  MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPGSLIAS IASLKHGGCN KVLRELVKHK
    61  LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ MGVGKESDIY IVANEEGQQF
   121  ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW LYLSRLSAMK EFAYMKALYE RKFPVPKPID
   181  YNRHAVVMEL INGYPLCQIH HVEDPASVYD EAMELIVKLA NHGLIHGDFN EFNLILDESD
   241  HITMIDFPQM VSTSHPNAEW YFDRDVKCIK DFFMKRFSYE SELFPTFKDI RREDTLDVEV
   301  SASGYTKEMQ ADDELLHPLG PDDKNIETKE GSEFSFSDGE VAEKAEVYGS ENESERNCLE
   361  ESEGCYCRSS GDPEQIKEDS LSEESADARS FEMTEFNQAL EEIKGQVVEN NSVTEFSEEK
   421  NRTENYNRQD GQRVQGGVPA GSDEYEDECP HLIALSSLNR EFRPFRDEEN VGAMNQYRTR
   481  TLSITSSGSA VSCSTIPPEL VKQKVKRQLT KQQKSAVRRR LQKGEANIFT KQRRENMQNI
   541  KSSLEAASFW GE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIOK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 20 nTPM
skeletal muscle: 20 nTPM
retina: 18 nTPM
liver: 17 nTPM
pancreas: 16 nTPM
heart muscle: 16 nTPM

Single-cell type

pancreatic acinar cells: 40 nCPM
oocytes: 37 nCPM
erythrocyte progenitors: 36 nCPM
extravillous trophoblasts: 35 nCPM
pdcs: 35 nCPM
plasma cells: 32 nCPM

Immune cell

naive CD8 T-cell: 37 nTPM
MAIT T-cell: 35 nTPM
naive CD4 T-cell: 34 nTPM
T-reg: 32 nTPM
memory CD4 T-cell: 32 nTPM
intermediate monocyte: 31 nTPM

Brain region

cerebellum: 22 nTPM
white matter: 20 nTPM
hypothalamus: 18 nTPM
cerebral cortex: 17 nTPM
choroid plexus: 17 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 0.85
DepMap mean gene effect: -0.98
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

maturation of SSU-rRNA
positive regulation of rRNA processing
protein autophosphorylation
regulation of mitotic metaphase/anaphase transition
ribosomal small subunit biogenesis
positive regulation of ribosomal small subunit export from nucleus

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RIO kinase
Protein kinase-like domain superfamily
RIO-type domain
RIO kinase, conserved site
Winged helix-like DNA-binding domain superfamily
Winged helix DNA-binding domain superfamily
RIO domain
RIO2 kinase winged helix domain, N-terminal
Serine/threonine-protein kinase Rio2
Rio2, N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIOK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIOK2 as an antibody target. Whether an autoantibody or antibody against RIOK2 could matter depends on whether native RIOK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIOK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIOK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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