TIGD5

Protein identityUniProt · HPA

UniProt accession

Q53EQ6

Gene

TIGD5

Ensembl

ENSG00000179886

Chromosome

8

Canonical length

642 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

642 residues, UniProt reviewed canonical sequence.

>Q53EQ6|TIGD5
     1  MYPAGPPAGP VPRRGRRPLP GPPAPAPAPV PAARPPPPAP GPRPRVAVKM AFRKAYSIKD
    61  KLQAIERVKG GERQASVCRD FGVPGGTLRG WLKDEPKLRW FLEQLGGEVG TQRKKMRLAN
   121  EEEIDRAVYA WFLALRQHGV PLSGPLIQAQ AEAFARQIYG PECTFKASHG WFWRWQKRHG
   181  ISSQRFYGEA GPPAPSPAPG PPVKEEPALP SGAGPLPDRA PAPPPPAEGG YGDEQIYSAS
   241  VTGLYWKLLP EQAAPPGAGD PGAGGCGRRW RGDRVTVLLA ANLTGSHKLK PLVIGRLPDP
   301  PSLRHHNQDK FPASYRYSPD AWLSRPLLRG WFFEEFVPGV KRYLRRSCLQ QKAVLLVAHP
   361  PCPSPAASMP ALDSEDAPVR CRPEPLGPPE ELQTPDGAVR VLFLSKGSSR AHIPAPLEQG
   421  VVAAFKQLYK RELLRLAVSC ASGSPLDFMR SFMLKDMLYL AGLSWDLVQA GSIERCWLLG
   481  LRAAFEPRPG EDSAGQPAQA EEAAEHSRVL SDLTHLAALA YKCLAPEEVA EWLHLDDDGG
   541  PPEGCREEVG PALPPAAPPA PASLPSAMGG GEDEEEATDY GGTSVPTAGE AVRGLETALR
   601  WLENQDPREV GPLRLVQLRS LISMARRLGG IGHTPAGPYD GV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIGD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

5.6 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.91

gnomAD pLI

0

gnomAD missense Z

1.73

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• central nervous system formation
• segment specification

Molecular functions

• DNA binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• DDE superfamily endonuclease domain
• HTH CenpB-type DNA-binding domain
• DNA binding HTH domain, Psq-type
• Homedomain-like superfamily
• Winged helix-like DNA-binding domain superfamily
• Centromere and Transposable Element-Derived Protein
• DDE superfamily endonuclease
• Tc5 transposase DNA-binding domain
• CENP-B N-terminal DNA-binding domain

KeywordsUniProt

• DNA-binding
• Nucleus
• Repeat

InteractionsUniProt · HPA

Protein binding partners of TIGD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAGEA4