Seroatlas · Human Serome Atlas

TADA2A

Transcriptional adapter 2-alpha

Also known as: TAD2A_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75478
Gene: TADA2A
Canonical length: 443 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for TADA2A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>O75478|TADA2A
     1  MDRLGPFSND PSDKPPCRGC SSYLMEPYIK CAECGPPPFF LCLQCFTRGF EYKKHQSDHT
    61  YEIMTSDFPV LDPSWTAQEE MALLEAVMDC GFGNWQDVAN QMCTKTKEEC EKHYMKHFIN
   121  NPLFASTLLN LKQAEEAKTA DTAIPFHSTD DPPRPTFDSL LSRDMAGYMP ARADFIEEFD
   181  NYAEWDLRDI DFVEDDSDIL HALKMAVVDI YHSRLKERQR RKKIIRDHGL INLRKFQLME
   241  RRYPKEVQDL YETMRRFARI VGPVEHDKFI ESHALEFELR REIKRLQEYR TAGITNFCSA
   301  RTYDHLKKTR EEERLKRTML SEVLQYIQDS SACQQWLRRQ ADIDSGLSPS IPMASNSGRR
   361  SAPPLNLTGL PGTEKLNEKE KELCQMVRLV PGAYLEYKSA LLNECNKQGG LRLAQARALI
   421  KIDVNKTRKI YDFLIREGYI TKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TADA2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 9.9 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 9.9 nTPM
testis: 9.4 nTPM
cerebral cortex: 7.4 nTPM
hypothalamus: 6.2 nTPM
midbrain: 6.2 nTPM
basal ganglia: 6.1 nTPM

Single-cell type

late spermatids: 52 nCPM
renal collecting duct intercalated cells: 42 nCPM
microglia: 42 nCPM
renal connecting tubule cells: 39 nCPM
renal collecting duct principal cells: 38 nCPM
brain excitatory neurons: 35 nCPM

Immune cell

plasmacytoid DC: 8.6 nTPM
naive B-cell: 7.1 nTPM
non-classical monocyte: 6 nTPM
gdT-cell: 5.4 nTPM
naive CD4 T-cell: 5.3 nTPM
naive CD8 T-cell: 5.1 nTPM

Brain region

cerebellum: 16 nTPM
cerebral cortex: 14 nTPM
white matter: 14 nTPM
thalamus: 12 nTPM
basal ganglia: 12 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 1.46
DepMap mean gene effect: -0.56
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TADA2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TADA2A as an antibody target. Whether an autoantibody or antibody against TADA2A could matter depends on whether native TADA2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TADA2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TADA2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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