Seroatlas · Human Serome Atlas

FOXD4L1

Forkhead box protein D4-like 1

Also known as: FOXD5, FX4L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NU39
Gene: FOXD4L1
Ensembl: ENSG00000184492
Chromosome: 2
Canonical length: 408 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is a member of the forkhead/winged-helix (FOX) family of transcription factors with highly conserved FOX DNA-binding domains. Members of the FOX family of transcription factors are regulators of embryogenesis and may play a role in human cancer. This gene lies in a region of chromosome 2 that surrounds the site where two ancestral chromosomes fused to form human chromosome 2. This region is duplicated elsewhere in the human genome, primarily in subtelomeric and pericentromeric locations, thus mutiple copies of this gene have been found. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>Q9NU39|FOXD4L1
     1  MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEASQKF LEQSLQPGLQ
    61  VARWGGVALP REHIEGGGPS DPSEFGTEFR APPRSAAASE DARQPAKPPY SYIALITMAI
   121  LQSPHKRLTL SGICAFISGR FPYYRRKFPA WQNSIRHNLS LNDCFVKIPR EPGHPGKGTY
   181  WSLDPASQDM FDNGSFLRRR KRFKRHQLTP GAHLPHPFPL PAAHAALHNP RPGPLLGAPA
   241  LPQPVPGAYP NTAPGRRPYA LLHPHPPRYL LLSAPAYAGA PKKAEGADLA TPGTLPVLQP
   301  SLGPQPWEEG KGLASPPGGG CISFSIESIM QGVRGAGTGA AQSLSPTAWS YCPLLQRPSS
   361  LSDNFAATAA ASGGGLRQRL RSHQGRGAGR APVGRVGAAA VSGGGRGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXD4L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 1.1 nTPM

Expression across tissuesHPA

Tissue

testis: 1.1 nTPM
cerebellum: 1 nTPM
bone marrow: 0.5 nTPM
basal ganglia: 0.3 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Single-cell type

cholangiocytes: 2 nCPM
sertoli cells: 1.1 nCPM
retinal bipolar cells: 0.5 nCPM
alveolar cells type 1: 0.4 nCPM
megakaryocyte progenitors: 0.4 nCPM
cdc: 0.3 nCPM

Immune cell

naive B-cell: 0.6 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hippocampal formation: 1.3 nTPM
cerebral cortex: 1.2 nTPM
white matter: 1 nTPM
cerebellum: 0.9 nTPM
pons: 0.7 nTPM
amygdala: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0.01
gnomAD missense Z: -0.32

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXD4L1 as an antibody target. Whether an autoantibody or antibody against FOXD4L1 could matter depends on whether native FOXD4L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXD4L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXD4L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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