ELK4
ETS domain-containing protein Elk-4
Also known as: ELK4_HUMAN, SAP1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P28324
- Gene
- ELK4
- Ensembl
- ENSG00000158711
- Chromosome
- 1
- Canonical length
- 431 aa
- Protein class
- Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
431 residues, UniProt reviewed canonical sequence.
>P28324|ELK4
1 MDSAITLWQF LLQLLQKPQN KHMICWTSND GQFKLLQAEE VARLWGIRKN KPNMNYDKLS
61 RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LNMDPMTVGR IEGDCESLNF SEVSSSSKDV
121 ENGGKDKPPQ PGAKTSSRND YIHSGLYSSF TLNSLNSSNV KLFKLIKTEN PAEKLAEKKS
181 PQEPTPSVIK FVTTPSKKPP VEPVAATISI GPSISPSSEE TIQALETLVS PKLPSLEAPT
241 SASNVMTAFA TTPPISSIPP LQEPPRTPSP PLSSHPDIDT DIDSVASQPM ELPENLSLEP
301 KDQDSVLLEK DKVNNSSRSK KPKGLELAPT LVITSSDPSP LGILSPSLPT ASLTPAFFSQ
361 TPIILTPSPL LSSIHFWSTL SPVAPLSPAR LQGANTLFQF PSVLNSHGPF TLSGLDGPST
421 PGPFSPDLQK TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ELK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- prostate: 24 nTPM
- lymph node: 16 nTPM
- tonsil: 16 nTPM
- spleen: 15 nTPM
- thymus: 13 nTPM
- skin: 13 nTPM
Single-cell type
- prostatic glandular cells: 569 nCPM
- endometrial glandular cells: 166 nCPM
- retinal bipolar cells: 97 nCPM
- renal collecting duct intercalated cells: 88 nCPM
- lymphatic endothelial cells: 76 nCPM
- urothelial cells: 76 nCPM
Immune cell
- basophil: 6.7 nTPM
- naive CD8 T-cell: 1.6 nTPM
- MAIT T-cell: 1.1 nTPM
- memory CD8 T-cell: 1.1 nTPM
- naive B-cell: 1.1 nTPM
- naive CD4 T-cell: 1.1 nTPM
Brain region
- white matter: 42 nTPM
- cerebellum: 39 nTPM
- basal ganglia: 36 nTPM
- pons: 34 nTPM
- spinal cord: 34 nTPM
- thalamus: 33 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.92
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.48
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell differentiation
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
Molecular functions
- chromatin binding
- DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ELK4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ELK4 as an antibody target. Whether an autoantibody or antibody against ELK4 could matter depends on whether native ELK4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ELK4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ELK4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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