Seroatlas · Human Serome Atlas

PLEK

Pleckstrin

Also known as: P47, PLEK_HUMAN, PLEK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P08567
Gene: PLEK
Ensembl: ENSG00000115956
Chromosome: 2
Canonical length: 350 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of actin filament organization; and regulation of phosphate metabolic process. Located in cytoplasm and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>P08567|PLEK
     1  MEPKRIREGY LVKKGSVFNT WKPMWVVLLE DGIEFYKKKS DNSPKGMIPL KGSTLTSPCQ
    61  DFGKRMFVFK ITTTKQQDHF FQAAFLEERD AWVRDIKKAI KCIEGGQKFA RKSTRRSIRL
   121  PETIDLGALY LSMKDTEKGI KELNLEKDKK IFNHCFTGNC VIDWLVSNQS VRNRQEGLMI
   181  ASSLLNEGYL QPAGDMSKSA VDGTAENPFL DNPDAFYYFP DSGFFCEENS SDDDVILKEE
   241  FRGVIIKQGC LLKQGHRRKN WKVRKFILRE DPAYLHYYDP AGAEDPLGAI HLRGCVVTSV
   301  ESNSNGRKSE EENLFEIITA DEVHYFLQAA TPKERTEWIR AIQMASRTGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 571 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 571 nTPM
lymph node: 122 nTPM
tonsil: 111 nTPM
appendix: 94 nTPM
spleen: 88 nTPM
urinary bladder: 49 nTPM

Single-cell type

megakaryocytes: 6,979 nCPM
neutrophils: 5,200 nCPM
megakaryocyte progenitors: 1,906 nCPM
platelets: 917 nCPM
monocytes: 873 nCPM
neutrophil progenitors: 513 nCPM

Immune cell

total PBMC: 606 nTPM
neutrophil: 576 nTPM
plasmacytoid DC: 476 nTPM
eosinophil: 430 nTPM
non-classical monocyte: 392 nTPM
intermediate monocyte: 352 nTPM

Brain region

white matter: 20 nTPM
cerebral cortex: 15 nTPM
medulla oblongata: 11 nTPM
spinal cord: 9.9 nTPM
pons: 9.6 nTPM
thalamus: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEK as an antibody target. Whether an autoantibody or antibody against PLEK could matter depends on whether native PLEK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEK is annotated at the cell surface, where native PLEK is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLEK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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