RGS6

Protein identityUniProt · HPA

UniProt accession

P49758

Gene

RGS6

Ensembl

ENSG00000182732

Chromosome

14

Canonical length

472 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Vesicles

OverviewNCBI Gene

This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>P49758|RGS6
     1  MAQGSGDQRA VGVADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK SFLSKIPSVV
    61  TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH VLTMKDDGTF YRFQAPYFWP
   121  SNCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKI
   181  DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTEES
   241  QAQSPVHVLS QPIRKTTKED IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPLI
   301  TPAEPSNPWI SDDVALWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF LRFLESEFSS
   361  ENLRFWLAVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI NLDSHSYEIT SQNVKDGGRY
   421  TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL LLAKKKGKSL AGKRLTGLMQ SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.4

gnomAD pLI

0.44

gnomAD missense Z

1.7

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled receptor signaling pathway
• intracellular signal transduction
• negative regulation of signal transduction
• positive regulation of GTPase activity
• regulation of G protein-coupled receptor signaling pathway

Molecular functions

• GTPase activator activity
• GTPase activity

Cellular components

• cytoplasm
• cytosol
• membrane
• neuron projection
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• DEP domain
• G-protein, gamma subunit-like domain
• RGS domain
• G-protein gamma-like domain superfamily
• RGS domain superfamily
• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• Regulator of G-protein signalling, DHEX domain
• RGS, subdomain 2
• Regulator of G protein signaling 6/7/9/11
• Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily
• Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
• Regulator of G protein signaling domain
• GGL domain
• Regulator of G-protein signalling DHEX domain
• RGS6, RGS domain

KeywordsUniProt

• Cell membrane
• Cytoplasm
• GTPase activation
• Membrane
• Nucleus
• Signal transduction inhibitor

InteractionsUniProt · HPA

Protein binding partners of RGS6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GNAI1
• GNB5
• RGS7BP