Seroatlas · Human Serome Atlas

FOXN2

Forkhead box protein N2

Also known as: FOXN2_HUMAN, HTLF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P32314
Gene: FOXN2
Ensembl: ENSG00000170802
Chromosome: 2
Canonical length: 431 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>P32314|FOXN2
     1  MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE SADDELTNLN
    61  WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC YQNPEKKSAT SKPPYSFSLL
   121  IYMAIEHSPN KCLPVKEIYS WILDHFPYFA TAPTGWKNSV RHNLSLNKCF QKVERSHGKV
   181  NGKGSLWCVD PEYKPNLIQA LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA
   241  AAAMMLLNTS IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE
   301  DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE EDTDVDYEDD
   361  PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA AGSLLHLAGI RTCLGSLIST
   421  AKTQNQKQRK K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 51 nTPM
liver: 19 nTPM
lymph node: 18 nTPM
spleen: 17 nTPM
adipose tissue: 17 nTPM
tonsil: 16 nTPM

Single-cell type

neutrophils: 472 nCPM
neutrophil progenitors: 404 nCPM
oligodendrocytes: 360 nCPM
monocyte progenitors: 300 nCPM
oligodendrocyte progenitor cells: 243 nCPM
cdc: 230 nCPM

Immune cell

eosinophil: 120 nTPM
basophil: 113 nTPM
neutrophil: 38 nTPM
non-classical monocyte: 33 nTPM
myeloid DC: 30 nTPM
classical monocyte: 29 nTPM

Brain region

white matter: 111 nTPM
basal ganglia: 71 nTPM
cerebellum: 63 nTPM
medulla oblongata: 60 nTPM
midbrain: 54 nTPM
pons: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.5
gnomAD missense Z: -0.59
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Fork head domain
Fork head domain conserved site1
Fork head domain conserved site 2
Winged helix-like DNA-binding domain superfamily
Winged helix DNA-binding domain superfamily
Forkhead box protein N2/3-like
Forkhead domain
Forkhead box protein N2, forkhead domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FOXN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXN2 as an antibody target. Whether an autoantibody or antibody against FOXN2 could matter depends on whether native FOXN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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