Seroatlas · Human Serome Atlas

IRF1

Interferon regulatory factor 1

Also known as: IRF1_HUMAN, MAR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P10914
Gene
IRF1
Ensembl
ENSG00000125347
Chromosome
5
Canonical length
325 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>P10914|IRF1
     1  MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK DACLFRSWAI
    61  HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPPLTKNQR
   121  KERKSKSSRD AKSKAKRKSC GDSSPDTFSD GLSSSTLPDD HSSYTVPGYM QDLEVEQALT
   181  PALSPCAVSS TLPDWHIPVE VVPDSTSDLY NFQVSPMPST SEATTDEDEE GKLPEDIMKL
   241  LEQSEWQPTN VDGKGYLLNE PGVQPTSVYG DFSCKEEPEI DSPGGDIGLS LQRVFTDLKN
   301  MDATWLDSLL TPVRLPSIQA IPCAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
134 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 134 nTPM
  • lung: 98 nTPM
  • spleen: 95 nTPM
  • appendix: 83 nTPM
  • lymph node: 81 nTPM
  • duodenum: 80 nTPM

Single-cell type

  • neutrophils: 756 nCPM
  • salivary myoepithelial cells: 621 nCPM
  • epididymal basal cells: 585 nCPM
  • smooth muscle cells: 568 nCPM
  • cardiomyocytes: 491 nCPM
  • fallopian tube ciliated cells: 473 nCPM

Immune cell

  • neutrophil: 624 nTPM
  • non-classical monocyte: 274 nTPM
  • eosinophil: 258 nTPM
  • intermediate monocyte: 244 nTPM
  • basophil: 176 nTPM
  • classical monocyte: 167 nTPM

Brain region

  • medulla oblongata: 32 nTPM
  • pons: 29 nTPM
  • thalamus: 18 nTPM
  • spinal cord: 14 nTPM
  • cerebral cortex: 14 nTPM
  • amygdala: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IRF1.

Disease | AllUniProt

Conditions IRF1 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
0.99
gnomAD missense Z
2.35
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IRF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRF1 as an antibody target. Whether an autoantibody or antibody against IRF1 could matter depends on whether native IRF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IRF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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