Seroatlas · Human Serome Atlas

COPS4

COP9 signalosome complex subunit 4

Also known as: CSN4, CSN4_HUMAN, SGN4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BT78
Gene
COPS4
Ensembl
ENSG00000138663
Chromosome
4
Canonical length
406 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q9BT78|COPS4
     1  MAAAVRQDLA QLMNSSGSHK DLAGKYRQIL EKAIQLSGAE QLEALKAFVE AMVNENVSLV
    61  ISRQLLTDFC THLPNLPDST AKEIYHFTLE KIQPRVISFE EQVASIRQHL ASIYEKEEDW
   121  RNAAQVLVGI PLETGQKQYN VDYKLETYLK IARLYLEDDD PVQAEAYINR ASLLQNESTN
   181  EQLQIHYKVC YARVLDYRRK FIEAAQRYNE LSYKTIVHES ERLEALKHAL HCTILASAGQ
   241  QRSRMLATLF KDERCQQLAA YGILEKMYLD RIIRGNQLQE FAAMLMPHQK ATTADGSSIL
   301  DRAVIEHNLL SASKLYNNIT FEELGALLEI PAAKAEKIAS QMITEGRMNG FIDQIDGIVH
   361  FETREALPTW DKQIQSLCFQ VNNLLEKISQ TAPEWTAQAM EAQMAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
98 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 98 nTPM
  • tongue: 79 nTPM
  • heart muscle: 56 nTPM
  • retina: 42 nTPM
  • testis: 42 nTPM
  • cerebral cortex: 42 nTPM

Single-cell type

  • late primary spermatocytes: 272 nCPM
  • oocytes: 184 nCPM
  • syncytiotrophoblasts: 139 nCPM
  • megakaryocytes: 111 nCPM
  • cytotrophoblasts: 109 nCPM
  • early spermatids: 107 nCPM

Immune cell

  • basophil: 92 nTPM
  • non-classical monocyte: 60 nTPM
  • eosinophil: 55 nTPM
  • NK-cell: 55 nTPM
  • MAIT T-cell: 54 nTPM
  • total PBMC: 52 nTPM

Brain region

  • hypothalamus: 47 nTPM
  • pons: 41 nTPM
  • basal ganglia: 37 nTPM
  • cerebral cortex: 36 nTPM
  • midbrain: 36 nTPM
  • white matter: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
3.14
DepMap mean gene effect
-1.12
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPS4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPS4 as an antibody target. Whether an autoantibody or antibody against COPS4 could matter depends on whether native COPS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COPS4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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