Seroatlas · Human Serome Atlas

ASMT

Acetylserotonin O-methyltransferase

Also known as: ASMT_HUMAN, ASMTY, HIOMT, HIOMTY

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P46597
Gene: ASMT
Ensembl: ENSG00000196433
Chromosome: X
Canonical length: 345 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>P46597|ASMT
     1  MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT
    61  ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL
   121  ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF
   181  PLMCDLGGGA GALAKECMSL YPGCKITVFD IPEVVWTAKQ HFSFQEEEQI DFQEGDFFKD
   241  PLPEADLYIL ARVLHDWADG KCSHLLERIY HTCKPGGGIL VIESLLDEDR RGPLLTQLYS
   301  LNMLVQTEGQ ERTPTHYHML LSSAGFRDFQ FKKTGAIYDA ILARK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 7.2 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 7.2 nTPM
epididymis: 1.7 nTPM
pituitary gland: 1.4 nTPM
adrenal gland: 0.7 nTPM
bone marrow: 0.7 nTPM
cervix: 0.7 nTPM

Single-cell type

oocytes: 4.6 nCPM
epididymal clear cells: 4.1 nCPM
extravillous trophoblasts: 2.7 nCPM
thymocytes: 2.5 nCPM
epicardial cells: 2.3 nCPM
epididymal principal cells: 2.2 nCPM

Immune cell

naive B-cell: 2.1 nTPM
memory B-cell: 0.6 nTPM
memory CD8 T-cell: 0.6 nTPM
NK-cell: 0.4 nTPM
memory CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM

Brain region

choroid plexus: 3.1 nTPM
hypothalamus: 2.5 nTPM
cerebellum: 1.4 nTPM
cerebral cortex: 1.3 nTPM
white matter: 1.2 nTPM
basal ganglia: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -1.7

OntologyGO

Biological processes

Molecular functions

identical protein binding
O-methyltransferase activity
protein homodimerization activity
acetylserotonin O-methyltransferase activity
S-methyltransferase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASMT as an antibody target. Whether an autoantibody or antibody against ASMT could matter depends on whether native ASMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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