DVL1P1
Putative segment polarity protein dishevelled homolog DVL1P1
Also known as: DVLP1_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for DVL1P1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
670 residues, UniProt reviewed canonical sequence.
>P54792|DVL1P1
1 MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK SMDQDFGVVK
61 EEIFDDNAKL PCFNGRVVSW LVLVEGAHSD AGSQGTDSHT DLPPPLERTG GIGDSRSPSF
121 QPDVASSRDG MDNETGTESM VSHRRDRARR RNREEAARTN GHPRGDRRRD VGLPPDSAST
181 ALSSELESSS FVDSDEDDST SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSM
241 TDSTMSLNII TVTLNMERHH FLGICIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM
301 LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP RPDPVRPIDP
361 AAWLSHTAAL TGALPRPQLE EAPLTVESDM NTVVRVMQLP DSGLEIRDRM WLKITIANAV
421 IGADVVDWLY THVEGFKERR EARKYASSLL KHGFLRHTVN KITFSEQCYY VFGDLCSNLA
481 TLNLNSGSSG TSDQDTLAPL PHPAAPWPLG QGYPYQYPGP PPCFPPAYQD PGFSYGSGST
541 GSQQSEGSKS SGSTRNTLRP PACEKERRAA GSGDSDSESD HTAPSGVGSS WRERPADQLS
601 RGSSPRSQAS SYAPGLPPPH PTTKAYTVVG GPPGGPPVRE LAAVPPELTG SRQSFQKAMG
661 NPCEFFVDIMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DVL1P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
OntologyGO
Biological processes
- canonical Wnt signaling pathway
- heart development
- intracellular signal transduction
- positive regulation of transcription by RNA polymerase II
- Wnt signaling pathway, planar cell polarity pathway
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- DEP domain
- DIX domain
- PDZ domain
- Dishevelled protein domain
- Dishevelled family
- Dishevelled-related protein
- Dishevelled C-terminal
- Ubiquitin-like domain superfamily
- PDZ superfamily
- Winged helix-like DNA-binding domain superfamily
- Winged helix DNA-binding domain superfamily
- DIX domain superfamily
- PDZ domain
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DIX domain
- Dishevelled specific domain
- Segment polarity protein dishevelled (Dsh) C terminal
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DVL1P1 as an antibody target. Whether an autoantibody or antibody against DVL1P1 could matter depends on whether native DVL1P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DVL1P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DVL1P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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