EIF3CL

Protein identityUniProt · HPA

UniProt accession

B5ME19

Gene

EIF3CL

Ensembl

ENSG00000205609

Chromosome

16

Canonical length

914 aa

Protein class

Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

914 residues, UniProt reviewed canonical sequence.

>B5ME19|EIF3CL
     1  MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR SAKDKRFEEL
    61  TNLIRTIRNA MKIRDVTKCL EEFELLGKAY GKAKSIVDKE GVPRFYIRIL ADLEDYLNEL
   121  WEDKEGKKKM NKNNAKALST LRQKIRKYNR DFESHITSYK QNPEQSADED AEKNEEDSEG
   181  SSDEDEDEDG VSAATFLKKK SEAPSGESRK FLKKMDDEDE DSEDSEDDED WDTGSTSSDS
   241  DSEEEEGKQT ALASRFLKKA PTTDEDKKAA EKKREDKAKK KHDRKSKRLD EEEEEDNEGG
   301  EWERVRGGVP LVKEKPKMFA KGTEITHAVV IKKLNEILQA RGKKGTDRAA QIELLQLLVQ
   361  IAAENNLGEG VIVKIKFNII ASLYDYNPNL ATYMKPEMWG KCLDCINELM DILFANPNIF
   421  VGENILEESE NLHNADQPLR VRGCILTLVE RMDEEFTKIM QNTDPHSQEY VEHLKDEAQV
   481  CAIIERVQRY LEEKGTTEEV CRIYLLRILH TYYKFDYKAH QRQLTPPEGS SKSEQDQAEN
   541  EGEDSAVLME RLCKYIYAKD RTDRIRTCAI LCHIYHHALH SRWYQARDLM LMSHLQDNIQ
   601  HADPPVQILY NRTMVQLGIC AFRQGLTKDA HNALLDIQSS GRAKELLGQG LLLRSLQERN
   661  QEQEKVERRR QVPFHLHINL ELLECVYLVS AMLLEIPYMA AHESDARRRM ISKQFHHQLR
   721  VGERQPLLGP PESMREHVVA ASKAMKMGDW KTCHSFIINE KMNGKVWDLF PEADKVRTML
   781  VRKIQEESLR TYLFTYSSVY DSISMETLSD MFELDLPTVH SIISKMIINE ELMASLDQPT
   841  QTVVMHRTEP TAQQNLALQL AEKLGSLVEN NERVFDHKQG TYGGYFRDQK DGYRKNEGYM
   901  RRGGYRQQQS QTAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3CL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

67 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.7

gnomAD pLI

0.01

gnomAD missense Z

0.91

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• formation of cytoplasmic translation initiation complex
• translational initiation

Molecular functions

• RNA binding
• translation initiation factor activity
• translation initiation factor binding

Cellular components

• eukaryotic 43S preinitiation complex
• eukaryotic 48S preinitiation complex
• eukaryotic translation initiation factor 3 complex

Protein domainsUniProt · Pfam · InterPro

• Proteasome component (PCI) domain
• Eukaryotic translation initiation factor 3 subunit C, N-terminal domain
• Eukaryotic translation initiation factor 3 subunit C
• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• EIF3CL-like, C-terminal domain
• PCI domain
• Eukaryotic translation initiation factor 3 subunit 8 N-terminus
• EIF3CL-like, C-terminal domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Initiation factor
• Phosphoprotein
• Protein biosynthesis

InteractionsUniProt · HPA

Protein binding partners of EIF3CL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EIF3H
• EIF3I