Seroatlas · Human Serome Atlas

HSFX3

Heat shock transcription factor, X-linked member 3

Also known as: HSFX3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GWH4
Gene
HSFX3
Ensembl
ENSG00000283697
Chromosome
X
Canonical length
333 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>A0A1B0GWH4|HSFX3
     1  MASQNTEQEY EAKLAPSVGG EPTSGGPSGS SPDPNPDSSE VLDRHEDQAM SQDPGSQDNS
    61  PPEDRNQRVV NVEDNHNLFR LSFPRKLWTI VEEDTFKSVS WNDDGDAVII DKDLFQREVL
   121  QRKGAERIFK TDSLTSFIRQ LNLYGFCKTR PSNSPGNKKM MIYCNSNFQR DKPRLLENIQ
   181  RKDALRNTAQ QATRVPTPKR KNLVATRRSL RIYHINARKE AIKMCQQGAP SVQGPSGTQS
   241  FRRSGMWSKK SATRHPLGNG PPQEPNGPSW EGTSGNVTFT SSATTWMEGT GILSSLVYSD
   301  NGSVMSLYNI CYYALLASLS VMSPNEPSDD EEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSFX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • adrenal gland: 1.2 nTPM
  • heart muscle: 0.4 nTPM
  • thymus: 0.3 nTPM
  • pituitary gland: 0.2 nTPM
  • liver: 0.1 nTPM

Single-cell type

  • late primary spermatocytes: 113 nCPM
  • early spermatids: 91 nCPM
  • late spermatids: 11 nCPM
  • peritubular myoid cells: 0.6 nCPM
  • prostatic glandular cells: 0.5 nCPM
  • cardiomyocytes: 0.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.8 nTPM
  • cerebral cortex: 0.8 nTPM
  • midbrain: 0.6 nTPM
  • choroid plexus: 0.5 nTPM
  • hippocampal formation: 0.5 nTPM
  • hypothalamus: 0.5 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSFX3 as an antibody target. Whether an autoantibody or antibody against HSFX3 could matter depends on whether native HSFX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSFX3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSFX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSFX3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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