Seroatlas · Human Serome Atlas

DEPDC1

DEP domain-containing protein 1A

Also known as: DEP.8, DEP1A_HUMAN, DEPDC1A, FLJ20354, SDP35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TB30
Gene: DEPDC1
Ensembl: ENSG00000024526
Chromosome: 1
Canonical length: 811 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

811 residues, UniProt reviewed canonical sequence.

>Q5TB30|DEPDC1
     1  MESQGVPPGP YRATKLWNEV TTSFRAGMPL RKHRQHFKKY GNCFTAGEAV DWLYDLLRNN
    61  SNFGPEVTRQ QTIQLLRKFL KNHVIEDIKG RWGSENVDDN NQLFRFPATS PLKTLPRRYP
   121  ELRKNNIENF SKDKDSIFKL RNLSRRTPKR HGLHLSQENG EKIKHEIINE DQENAIDNRE
   181  LSQEDVEEVW RYVILIYLQT ILGVPSLEEV INPKQVIPQY IMYNMANTSK RGVVILQNKS
   241  DDLPHWVLSA MKCLANWPRS NDMNNPTYVG FERDVFRTIA DYFLDLPEPL LTFEYYELFV
   301  NILVVCGYIT VSDRSSGIHK IQDDPQSSKF LHLNNLNSFK STECLLLSLL HREKNKEESD
   361  STERLQISNP GFQERCAKKM QLVNLRNRRV SANDIMGGSC HNLIGLSNMH DLSSNSKPRC
   421  CSLEGIVDVP GNSSKEASSV FHQSFPNIEG QNNKLFLESK PKQEFLLNLH SEENIQKPFS
   481  AGFKRTSTLT VQDQEELCNG KCKSKQLCRS QSLLLRSSTR RNSYINTPVA EIIMKPNVGQ
   541  GSTSVQTAME SELGESSATI NKRLCKSTIE LSENSLLPAS SMLTGTQSLL QPHLERVAID
   601  ALQLCCLLLP PPNRRKLQLL MRMISRMSQN VDMPKLHDAM GTRSLMIHTF SRCVLCCAEE
   661  VDLDELLAGR LVSFLMDHHQ EILQVPSYLQ TAVEKHLDYL KKGHIENPGD GLFAPLPTYS
   721  YCKQISAQEF DEQKVSTSQA AIAELLENII KNRSLPLKEK RKKLKQFQKE YPLIYQKRFP
   781  TTESEAALFG DKPTIKQPML ILRKPKFRSL R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEPDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

testis: 7.5 nTPM
thymus: 7.5 nTPM
bone marrow: 4.7 nTPM
lymph node: 4.5 nTPM
tonsil: 4.5 nTPM
rectum: 3.3 nTPM

Single-cell type

late spermatids: 116 nCPM
late primary spermatocytes: 90 nCPM
early primary spermatocytes: 69 nCPM
monocyte progenitors: 61 nCPM
erythrocyte progenitors: 55 nCPM
megakaryocyte progenitors: 45 nCPM

Immune cell

T-reg: 0.5 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 0.9 nTPM
white matter: 0.9 nTPM
thalamus: 0.8 nTPM
cerebral cortex: 0.7 nTPM
pons: 0.6 nTPM
amygdala: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DEPDC1.

Disease | ImmuneIEDB

Conditions an epitope on DEPDC1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DEPDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZNF224

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEPDC1 as an antibody target. Whether an autoantibody or antibody against DEPDC1 could matter depends on whether native DEPDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEPDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DEPDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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