Seroatlas · Human Serome Atlas

RGS7

Regulator of G-protein signaling 7

Also known as: RGS7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49802
Gene
RGS7
Ensembl
ENSG00000182901
Chromosome
1
Canonical length
495 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitochondria,Cytosol

OverviewNCBI Gene

Enables G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and GTPase activator activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of G protein-coupled receptor signaling pathway; and positive regulation of GTPase activity. Located in cytosol. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>P49802|RGS7
     1  MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS
    61  DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC
   121  WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK
   181  RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH
   241  SPTHTPTPET KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY LEYDPFLLPP
   301  DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF LESEFSSENL
   361  RFWLAVEDLK KRPIKEVPSR VQEIWQEFLA PGAPSAINLD SKSYDKTTQN VKEPGRYTFE
   421  DAQEHIYKLM KSDSYPRFIR SSAYQELLQA KKKSGNSMDR RTSFEKFAQN VGRNIPIFPC
   481  HKNCTPTLRA STNLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 22 nTPM
  • cerebellum: 22 nTPM
  • basal ganglia: 14 nTPM
  • hippocampal formation: 7.7 nTPM
  • hypothalamus: 7.2 nTPM
  • amygdala: 6.8 nTPM

Single-cell type

  • retinal horizontal cells: 1,719 nCPM
  • brain excitatory neurons: 1,531 nCPM
  • brain inhibitory neurons: 1,407 nCPM
  • retinal bipolar cells: 1,084 nCPM
  • other brain neurons: 1,072 nCPM
  • adrenal medulla cells: 851 nCPM

Immune cell

  • plasmacytoid DC: 0.3 nTPM
  • basophil: 0.2 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebral cortex: 16 nTPM
  • cerebellum: 14 nTPM
  • hippocampal formation: 11 nTPM
  • basal ganglia: 11 nTPM
  • white matter: 11 nTPM
  • amygdala: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.78
gnomAD missense Z
2.47
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS7 as an antibody target. Whether an autoantibody or antibody against RGS7 could matter depends on whether native RGS7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS7 is annotated at the cell surface, where native RGS7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RGS7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RGS7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...