Seroatlas · Human Serome Atlas

PSMD12

26S proteasome non-ATPase regulatory subunit 12

Also known as: p55, PSD12_HUMAN, Rpn5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00232
Gene
PSMD12
Ensembl
ENSG00000197170
Chromosome
17
Canonical length
456 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Microtubules,Cytosol

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>O00232|PSMD12
     1  MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKEGRL QEVIETLLSL EKQTRTASDM
    61  VSTSRILVAV VKMCYEAKEW DLLNENIMLL SKRRSQLKQA VAKMVQQCCT YVEEITDLPI
   121  KLRLIDTLRM VTEGKIYVEI ERARLTKTLA TIKEQNGDVK EAASILQELQ VETYGSMEKK
   181  ERVEFILEQM RLCLAVKDYI RTQIISKKIN TKFFQEENTE KLKLKYYNLM IQLDQHEGSY
   241  LSICKHYRAI YDTPCIQAES EKWQQALKSV VLYVILAPFD NEQSDLVHRI SGDKKLEEIP
   301  KYKDLLKLFT TMELMRWSTL VEDYGMELRK GSLESPATDV FGSTEEGEKR WKDLKNRVVE
   361  HNIRIMAKYY TRITMKRMAQ LLDLSVDESE AFLSNLVVNK TIFAKVDRLA GIINFQRPKD
   421  PNNLLNDWSQ KLNSLMSLVN KTTHLIAKEE MIHNLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMD12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 36 nTPM
  • tongue: 27 nTPM
  • liver: 26 nTPM
  • midbrain: 16 nTPM
  • cerebral cortex: 15 nTPM
  • pancreas: 15 nTPM

Single-cell type

  • late spermatids: 304 nCPM
  • endometrial glandular cells: 227 nCPM
  • erythrocyte progenitors: 204 nCPM
  • early spermatids: 199 nCPM
  • thymic myoid cells: 175 nCPM
  • endometrial luminal cells: 166 nCPM

Immune cell

  • non-classical monocyte: 20 nTPM
  • intermediate monocyte: 17 nTPM
  • basophil: 14 nTPM
  • MAIT T-cell: 12 nTPM
  • T-reg: 12 nTPM
  • memory CD4 T-cell: 12 nTPM

Brain region

  • cerebral cortex: 43 nTPM
  • pons: 43 nTPM
  • midbrain: 41 nTPM
  • hypothalamus: 40 nTPM
  • medulla oblongata: 39 nTPM
  • thalamus: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSMD12.

Disease | AllUniProt

Conditions PSMD12 is implicated in, by any mechanism.

Disease | GeneticClinVar

33 pathogenic / likely-pathogenic of 173 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
1.87
DepMap mean gene effect
-1.87
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMD12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMD12 as an antibody target. Whether an autoantibody or antibody against PSMD12 could matter depends on whether native PSMD12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMD12 is annotated as secreted, so native PSMD12 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSMD12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMD12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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