FOXO6
Forkhead box protein O6
Also known as: FOXO6_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A8MYZ6
- Gene
- FOXO6
- Ensembl
- ENSG00000204060
- Chromosome
- 1
- Canonical length
- 492 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of dendritic spine development and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
492 residues, UniProt reviewed canonical sequence.
>A8MYZ6|FOXO6
1 MAAKLRAHQV DVDPDFAPQS RPRSCTWPLP QPDLAGDEDG ALGAGVAEGA EDCGPERRAT
61 APAMAPAPPL GAEVGPLRKA KSSRRNAWGN LSYADLITKA IESAPDKRLT LSQIYDWMVR
121 YVPYFKDKGD SNSSAGWKNS IRHNLSLHTR FIRVQNEGTG KSSWWMLNPE GGKTGKTPRR
181 RAVSMDNGAK FLRIKGKASK KKQLQAPERS PDDSSPSAPA PGPVPAAAKW AASPASHASD
241 DYEAWADFRG GGRPLLGEAA ELEDDEALEA LAPSSPLMYP SPASALSPAL GSRCPGELPR
301 LAELGGPLGL HGGGGAGLPE GLLDGAQDAY GPRPAPRPGP VLGAPGELAL AGAAAAYPGK
361 GAAPYAPPAP SRSALAHPIS LMTLPGEAGA AGLAPPGHAA AFGGPPGGLL LDALPGPYAA
421 AAAGPLGAAP DRFPADLDLD MFSGSLECDV ESIILNDFMD SDEMDFNFDS ALPPPPPGLA
481 GAPPPNQSWV PGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FOXO6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 0.3 nTPM
Expression across tissuesHPA
Tissue
- ovary: 0.3 nTPM
- pancreas: 0.2 nTPM
- thymus: 0.2 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- ependymal cells: 5.9 nCPM
- other brain neurons: 5.8 nCPM
- epicardial cells: 4.5 nCPM
- choroid plexus epithelial cells: 3.7 nCPM
- papillary tip epithelial cells: 3.5 nCPM
- oligodendrocytes: 3.2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 1.9 nTPM
- cerebral cortex: 1.2 nTPM
- basal ganglia: 1 nTPM
- hippocampal formation: 0.9 nTPM
- midbrain: 0.9 nTPM
- hypothalamus: 0.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.67
- gnomAD pLI
- 0.41
- gnomAD missense Z
- 1.32
OntologyGO
Biological processes
- memory
- positive regulation of dendritic spine development
- regulation of transcription by RNA polymerase II
Molecular functions
- beta-catenin binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FOXO6 as an antibody target. Whether an autoantibody or antibody against FOXO6 could matter depends on whether native FOXO6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FOXO6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FOXO6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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