RGS11

Protein identityUniProt · HPA

UniProt accession

O94810

Gene

RGS11

Ensembl

ENSG00000076344

Chromosome

16

Canonical length

467 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>O94810|RGS11
     1  MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW
    61  LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE
   121  LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL
   181  VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT
   241  RVKSSVCLEA YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW
   301  GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL VDAVYEQFLA
   361  PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM KKDSYPRFLK SDMYKALLAE
   421  AGIPLEMKRR VFPFTWRPRH SSPSPALLPT PVEPTAACGP GGGDGVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

164 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.11

gnomAD pLI

0

gnomAD missense Z

-0.65

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled receptor signaling pathway
• intracellular signal transduction
• negative regulation of signal transduction
• regulation of G protein-coupled receptor signaling pathway

Molecular functions

• G-protein beta-subunit binding
• GTPase activator activity
• GTPase activity

Cellular components

• cytoplasm
• neuron projection
• plasma membrane
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• DEP domain
• G-protein, gamma subunit-like domain
• RGS domain
• G-protein gamma-like domain superfamily
• RGS domain superfamily
• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• Regulator of G-protein signalling, DHEX domain
• RGS, subdomain 2
• Regulator of G protein signaling 6/7/9/11
• Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily
• Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
• Regulator of G protein signaling domain
• GGL domain
• Regulator of G-protein signalling DHEX domain

KeywordsUniProt

• Signal transduction inhibitor

InteractionsUniProt · HPA

Protein binding partners of RGS11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RGS7BP