FOXL3
Forkhead box protein L3
Also known as: FOXL3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A1W2PRP0
- Gene
- FOXL3
- Ensembl
- ENSG00000248767
- Chromosome
- 7
- Canonical length
- 233 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
233 residues, UniProt reviewed canonical sequence.
>A0A1W2PRP0|FOXL3
1 MFDSSQYPYN CFNYDADDYP AGSSDEDKRL TRPAYSYIAL IAMAIQQSPA GRVTLSGIYD
61 FIMRKFPYYR ANQRAWQNSI RHNLSLNSCF VKVPRSEGHE KGKGNYWTFA GGCESLLDLF
121 ENGNYRRRRR RRGPKREGPR GPRAGGAQGP SGPSEPPAAQ GRLAPDSAGE GAPGREPPAS
181 PAPPGKEHPR DLKFSIDYIL SSPDPFPGLK PPCLAQEGRY PRLENVGLHF WTMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FOXL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 2.6 nTPM
Expression across tissuesHPA
Tissue
- testis: 2.6 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 614 nCPM
- late primary spermatocytes: 95 nCPM
- early spermatids: 92 nCPM
- leydig cells: 1.9 nCPM
- undifferentiated spermatogonia: 1.1 nCPM
- early primary spermatocytes: 0.8 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.7 nTPM
- basal ganglia: 0.5 nTPM
- pons: 0.5 nTPM
- hypothalamus: 0.4 nTPM
- medulla oblongata: 0.3 nTPM
- cerebellum: 0.2 nTPM
OntologyGO
Biological processes
- anatomical structure morphogenesis
- cell differentiation
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FOXL3 as an antibody target. Whether an autoantibody or antibody against FOXL3 could matter depends on whether native FOXL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FOXL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FOXL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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