FOXM1
Forkhead box protein M1
Also known as: FKHL16, FOXM1_HUMAN, HFH-11, HNF-3, INS-1, MPHOSPH2, MPP2, TGT3, trident
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q08050
- Gene
- FOXM1
- Ensembl
- ENSG00000111206
- Chromosome
- 12
- Canonical length
- 763 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol
OverviewNCBI Gene
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Canonical amino-acid sequenceUniProt
763 residues, UniProt reviewed canonical sequence.
>Q08050|FOXM1
1 MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPAQQE SNQAEASKEV AESNSCKFPA
61 GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG
121 LRPQTQTSYD AKRTEVTLET LGPKPAARDV NLPRPPGALC EQKRETCADG EAAGCTINNS
181 LSNIQWLRKM SSDGLGSRSI KQEMEEKENC HLEQRQVKVE EPSRPSASWQ NSVSERPPYS
241 YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS
301 ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP
361 LGARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA
421 PKVLLAEEGI APLSSAGPGK EEKLLFGEGF SPLLPVQTIK EEEIQPGEEM PHLARPIKVE
481 SPPLEEWPSP APSFKEESSH SWEDSSQSPT PRPKKSYSGL RSPTRCVSEM LVIQHRERRE
541 RSRSRRKQHL LPPCVDEPEL LFSEGPSTSR WAAELPFPAD SSDPASQLSY SQEVGGPFKT
601 PIKETLPISS TPSKSVLPRT PESWRLTPPA KVGGLDFSPV QTSQGASDPL PDPLGLMDLS
661 TTPLQSAPPL ESPQRLLSSE PLDLISVPFG NSSPSDIDVP KPGSPEPQVS GLAANRSLTE
721 GLVLDTMNDS LSKILLDISF PGLDEDPLGP DNINWSQFIP ELQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FOXM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- thymus: 30 nTPM
- bone marrow: 24 nTPM
- testis: 20 nTPM
- tonsil: 14 nTPM
- rectum: 12 nTPM
- lymph node: 11 nTPM
Single-cell type
- monocyte progenitors: 62 nCPM
- erythrocyte progenitors: 61 nCPM
- megakaryocyte progenitors: 49 nCPM
- enteric transient amplifying cells: 34 nCPM
- late spermatids: 34 nCPM
- epicardial cells: 32 nCPM
Immune cell
- T-reg: 0.2 nTPM
- naive CD4 T-cell: 0.1 nTPM
- neutrophil: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- thalamus: 6.9 nTPM
- pons: 6.6 nTPM
- cerebral cortex: 6.4 nTPM
- cerebellum: 6.2 nTPM
- hippocampal formation: 6.2 nTPM
- white matter: 5.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.59
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.71
- DepMap mean gene effect
- -0.34
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- DNA damage response, signal transduction by p53 class mediator
- DNA repair
- G2/M transition of mitotic cell cycle
- negative regulation of DNA-templated transcription
- negative regulation of stress-activated MAPK cascade
- negative regulation of transcription by RNA polymerase II
- positive regulation of cell population proliferation
- positive regulation of DNA-templated transcription
- positive regulation of double-strand break repair
- positive regulation of transcription by RNA polymerase II
- regulation of cell cycle
- regulation of cell population proliferation
- regulation of mitotic cell cycle
- regulation of Ras protein signal transduction
- regulation of reactive oxygen species metabolic process
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA binding
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- protein kinase binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Fork head domain
- Fork head domain conserved site1
- Fork head domain conserved site 2
- Winged helix-like DNA-binding domain superfamily
- Winged helix DNA-binding domain superfamily
- Forkhead domain
- Forkhead box protein M1
- Forkhead box protein M1, forkhead domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FOXM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FOXM1 as an antibody target. Whether an autoantibody or antibody against FOXM1 could matter depends on whether native FOXM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FOXM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FOXM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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