Seroatlas · Human Serome Atlas

FOXR1

Forkhead box protein R1

Also known as: DLNB13, FOXN5, FOXR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PIV2
Gene: FOXR1
Ensembl: ENSG00000176302
Chromosome: 11
Canonical length: 292 aa
Protein class: Disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q6PIV2|FOXR1
     1  MGNELFLAFT TSHLPLAEQK LARYKLRIVK PPKLPLEKKP NPDKDGPDYE PNLWMWVNPN
    61  IVYPPGKLEV SGRRKREDLT STLPSSQPPQ KEEDASCSEA AGVESLSQSS SKRSPPRKRF
   121  AFSPSTWELT EEEEAEDQED SSSMALPSPH KRAPLQSRRL RQASSQAGRL WSRPPLNYFH
   181  LIALALRNSS PCGLNVQQIY SFTRKHFPFF RTAPEGWKNT VRHNLCFRDS FEKVPVSMQG
   241  GASTRPRSCL WKLTEEGHRR FAEEARALAS TRLESIQQCM SQPDVMPFLF DL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

testis: 4.1 nTPM
ovary: 0.9 nTPM
retina: 0.1 nTPM
thymus: 0.1 nTPM
thyroid gland: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

oocytes: 530 nCPM
differentiating spermatogonia: 25 nCPM
early primary spermatocytes: 20 nCPM
undifferentiated spermatogonia: 12 nCPM
hematopoietic stem cells: 1 nCPM
lacrimal acinar cells: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
hippocampal formation: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebellum: 0.2 nTPM
hypothalamus: 0.2 nTPM
medulla oblongata: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXR1 as an antibody target. Whether an autoantibody or antibody against FOXR1 could matter depends on whether native FOXR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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