Seroatlas · Human Serome Atlas

ANAPC2

Anaphase-promoting complex subunit 2

Also known as: ANC2_HUMAN, APC2, KIAA1406

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJX6
Gene
ANAPC2
Ensembl
ENSG00000176248
Chromosome
9
Canonical length
822 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

822 residues, UniProt reviewed canonical sequence.

>Q9UJX6|ANAPC2
     1  MAAAVVVAEG DSDSRPGQEL LVAWNTVSTG LVPPAALGLV SSRTSGAVPP KEEELRAAVE
    61  VLRGHGLHSV LEEWFVEVLQ NDLQANISPE FWNAISQCEN SADEPQCLLL LLDAFGLLES
   121  RLDPYLRSLE LLEKWTRLGL LMGTGAQGLR EEVHTMLRGV LFFSTPRTFQ EMIQRLYGCF
   181  LRVYMQSKRK GEGGTDPELE GELDSRYARR RYYRLLQSPL CAGCSSDKQQ CWCRQALEQF
   241  HQLSQVLHRL SLLERVSAEA VTTTLHQVTR ERMEDRCRGE YERSFLREFH KWIERVVGWL
   301  GKVFLQDGPA RPASPEAGNT LRRWRCHVQR FFYRIYASLR IEELFSIVRD FPDSRPAIED
   361  LKYCLERTDQ RQQLLVSLKA ALETRLLHPG VNTCDIITLY ISAIKALRVL DPSMVILEVA
   421  CEPIRRYLRT REDTVRQIVA GLTGDSDGTG DLAVELSKTD PASLETGQDS EDDSGEPEDW
   481  VPDPVDADPG KSSSKRRSSD IISLLVSIYG SKDLFINEYR SLLADRLLHQ FSFSPEREIR
   541  NVELLKLRFG EAPMHFCEVM LKDMADSRRI NANIREEDEK RPAEEQPPFG VYAVILSSEF
   601  WPPFKDEKLE VPEDIRAALE AYCKKYEQLK AMRTLSWKHT LGLVTMDVEL ADRTLSVAVT
   661  PVQAVILLYF QDQASWTLEE LSKAVKMPVA LLRRRMSVWL QQGVLREEPP GTFSVIEEER
   721  PQDRDNMVLI DSDDESDSGM ASQADQKEEE LLLFWTYIQA MLTNLESLSL DRIYNMLRMF
   781  VVTGPALAEI DLQELQGYLQ KKVRDQQLVY SAGVYRLPKN CS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANAPC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • testis: 24 nTPM
  • cerebellum: 22 nTPM
  • pancreas: 20 nTPM
  • liver: 19 nTPM
  • spleen: 19 nTPM
  • skin: 19 nTPM

Single-cell type

  • late spermatids: 86 nCPM
  • late primary spermatocytes: 57 nCPM
  • early spermatids: 39 nCPM
  • cytotrophoblasts: 32 nCPM
  • early primary spermatocytes: 31 nCPM
  • syncytiotrophoblasts: 30 nCPM

Immune cell

  • total PBMC: 1.1 nTPM
  • non-classical monocyte: 0.9 nTPM
  • classical monocyte: 0.6 nTPM
  • intermediate monocyte: 0.6 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • gdT-cell: 0.5 nTPM

Brain region

  • white matter: 27 nTPM
  • medulla oblongata: 24 nTPM
  • cerebral cortex: 22 nTPM
  • pons: 22 nTPM
  • basal ganglia: 20 nTPM
  • midbrain: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
2.41
DepMap mean gene effect
-1.17
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANAPC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANAPC2 as an antibody target. Whether an autoantibody or antibody against ANAPC2 could matter depends on whether native ANAPC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANAPC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANAPC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANAPC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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