Seroatlas · Human Serome Atlas

ETV3L

ETS translocation variant 3-like protein

Also known as: ETV3L_HUMAN, FLJ16478

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZN32
Gene: ETV3L
Ensembl: ENSG00000253831
Chromosome: 1
Canonical length: 361 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q6ZN32|ETV3L
     1  MHCSCLAEGI PANPGNWISG LAFPDWAYKA ESSPGSRQIQ LWHFILELLQ KEEFRHVIAW
    61  QQGEYGEFVI KDPDEVARLW GRRKCKPQMN YDKLSRALRY YYNKRILHKT KGKRFTYKFN
   121  FSKLIVVNYP LWEVRAPPSP HLLLGAPALC RPALVPVGVQ SELLHSMLFA HQAMVEQLTG
   181  QQTPRGPPET SGDKKGSSSS VYRLGSAPGP CRLGLCCHLG SVQGELPGVA SFTPPLPPPL
   241  PSNWTCLSGP FLPPLPSEQQ LPGAFKPDIL LPGPRSLPGA WHFPGLPLLA GLGQGAGERL
   301  WLLSLRPEGL EVKPAPMMEA KGGLDPREVF CPETRRLKTG EESLTSPNLE NLKAVWPLDP
   361  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ETV3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 8.7 nTPM
basal ganglia: 0.8 nTPM
breast: 0.7 nTPM
appendix: 0.3 nTPM
amygdala: 0.2 nTPM
thymus: 0.2 nTPM

Single-cell type

cdc: 7.1 nCPM
monocytes: 2.5 nCPM
breast secretory cells: 2.4 nCPM
macrophages: 2.3 nCPM
kupffer cells: 2 nCPM
prostatic club cells: 1.8 nCPM

Immune cell

classical monocyte: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 3.6 nTPM
hypothalamus: 3.5 nTPM
basal ganglia: 0.6 nTPM
thalamus: 0.5 nTPM
amygdala: 0.3 nTPM
cerebral cortex: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ETV3L as an antibody target. Whether an autoantibody or antibody against ETV3L could matter depends on whether native ETV3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ETV3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ETV3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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