Seroatlas · Human Serome Atlas

FOXK1

Forkhead box protein K1

Also known as: FOXK1_HUMAN, IMAGE:5164497

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P85037
Gene
FOXK1
Ensembl
ENSG00000164916
Chromosome
7
Canonical length
733 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Enables 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription cis-regulatory region binding activity. Involved in several processes, including intracellular glucose homeostasis; negative regulation of autophagy; and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

733 residues, UniProt reviewed canonical sequence.

>P85037|FOXK1
     1  MAEVGEDSGA RALLALRSAP CSPVLCAAAA AAAFPAAAPP PAPAQPQPPP GPPPPPPPPL
    61  PPGAIAGAGS SGGSSGVSGD SAVAGAAPAL VAAAAASVRQ SPGPALARLE GREFEFLMRQ
   121  PSVTIGRNSS QGSVDLSMGL SSFISRRHLQ LSFQEPHFYL RCLGKNGVFV DGAFQRRGAP
   181  ALQLPKQCTF RFPSTAIKIQ FTSLYHKEEA PASPLRPLYP QISPLKIHIP EPDLRSMVSP
   241  VPSPTGTISV PNSCPASPRG AGSSSYRFVQ NVTSDLQLAA EFAAKAASEQ QADTSGGDSP
   301  KDESKPPFSY AQLIVQAISS AQDRQLTLSG IYAHITKHYP YYRTADKGWQ NSIRHNLSLN
   361  RYFIKVPRSQ EEPGKGSFWR IDPASEAKLV EQAFRKRRQR GVSCFRTPFG PLSSRSAPAS
   421  PTHPGLMSPR SGGLQTPECL SREGSPIPHD PEFGSKLASV PEYRYSQSAP GSPVSAQPVI
   481  MAVPPRPSSL VAKPVAYMPA SIVTSQQPAG HAIHVVQQAP TVTMVRVVTT SANSANGYIL
   541  TSQGAAGGSH DAAGAAVLDL GSEARGLEEK PTIAFATIPA AGGVIQTVAS QMAPGVPGHT
   601  VTILQPATPV TLGQHHLPVR AVTQNGKHAV PTNSLAGNAY ALTSPLQLLA TQASSSAPVV
   661  VTRVCEVGPK EPAAAVAATA TTTPATATTA SASASSTGEP EVKRSRVEEP SGAVTTPAGV
   721  IAAAGPQGPG TGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 12 nTPM
  • adrenal gland: 11 nTPM
  • skeletal muscle: 10 nTPM
  • blood vessel: 9.5 nTPM
  • colon: 9.4 nTPM
  • skin: 9.2 nTPM

Single-cell type

  • somatotrophs: 469 nCPM
  • lactotrophs: 297 nCPM
  • adrenal cortex cells: 212 nCPM
  • late spermatids: 186 nCPM
  • thyrotrophs: 184 nCPM
  • basal keratinocytes: 158 nCPM

Immune cell

  • MAIT T-cell: 2.4 nTPM
  • naive CD4 T-cell: 1.8 nTPM
  • naive CD8 T-cell: 1.8 nTPM
  • gdT-cell: 1.7 nTPM
  • memory CD4 T-cell: 1.7 nTPM
  • memory CD8 T-cell: 1.7 nTPM

Brain region

  • medulla oblongata: 58 nTPM
  • hippocampal formation: 58 nTPM
  • thalamus: 57 nTPM
  • cerebral cortex: 57 nTPM
  • pons: 55 nTPM
  • midbrain: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.81
gnomAD missense Z
2.49
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FOXK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXK1 as an antibody target. Whether an autoantibody or antibody against FOXK1 could matter depends on whether native FOXK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOXK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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