Seroatlas · Human Serome Atlas

GPR155

Lysosomal cholesterol signaling protein

Also known as: DEP.7, DEPDC3, FLJ31819, LYCHS_HUMAN, PGR22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3F1
Gene: GPR155
Ensembl: ENSG00000163328
Chromosome: 2
Canonical length: 870 aa
Protein class: Predicted membrane proteins, Transporters
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables cholesterol binding activity. Involved in several processes, including cellular response to amino acid starvation; cellular response to cholesterol; and positive regulation of TORC1 signaling. Located in extracellular exosome. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

870 residues, UniProt reviewed canonical sequence.

>Q7Z3F1|GPR155
     1  MNSNLPAENL TIAVNMTKTL PTAVTHGFNS TNDPPSMSIT RLFPALLECF GIVLCGYIAG
    61  RANVITSTQA KGLGNFVSRF ALPALLFKNM VVLNFSNVDW SFLYSILIAK ASVFFIVCVL
   121  TLLVASPDSR FSKAGLFPIF ATQSNDFALG YPIVEALYQT TYPEYLQYIY LVAPISLMML
   181  NPIGFIFCEI QKWKDTQNAS QNKIKIVGLG LLRVLQNPIV FMVFIGIAFN FILDRKVPVY
   241  VENFLDGLGN SFSGSALFYL GLTMVGKIKR LKKSAFVVLI LLITAKLLVL PLLCREMVEL
   301  LDKGDSVVNH TSLSNYAFLY GVFPVAPGVA IFATQFNMEV EIITSGMVIS TFVSAPIMYV
   361  SAWLLTFPTM DPKPLAYAIQ NVSFDISIVS LISLIWSLAI LLLSKKYKQL PHMLTTNLLI
   421  AQSIVCAGMM IWNFVKEKNF VGQILVFVLL YSSLYSTYLW TGLLAISLFL LKKRERVQIP
   481  VGIIIISGWG IPALLVGVLL ITGKHNGDSI DSAFFYGKEQ MITTAVTLFC SILIAGISLM
   541  CMNQTAQAGS YEGFDQSQSH KVVEPGNTAF EESPAPVNEP ELFTSSIPET SCCSCSMGNG
   601  ELHCPSIEPI ANTSTSEPVI PSFEKNNHCV SRCNSQSCIL AQEEEQYLQS GDQQLTRHVL
   661  LCLLLIIGLF ANLSSCLWWL FNQEPGRLYV ELQFFCAVFN FGQGFISFGI FGLDKHLIIL
   721  PFKRRLEFLW NNKDTAENRD SPVSEEIKMT CQQFIHYHRD LCIRNIVKER RCGAKTSAGT
   781  FCGCDLVSWL IEVGLASDRG EAVIYGDRLV QGGVIQHITN EYEFRDEYLF YRFLQKSPEQ
   841  SPPAINANTL QQERYKEIEH SSPPSHSPKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR155 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 17
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 65 nTPM
stomach: 50 nTPM
kidney: 19 nTPM
pancreas: 17 nTPM
cerebral cortex: 16 nTPM
basal ganglia: 14 nTPM

Single-cell type

choroid plexus epithelial cells: 876 nCPM
parietal cells: 606 nCPM
melanocytes: 404 nCPM
adrenal medulla cells: 394 nCPM
schwann cells: 364 nCPM
neutrophils: 202 nCPM

Immune cell

neutrophil: 7.3 nTPM
non-classical monocyte: 5.7 nTPM
T-reg: 5.5 nTPM
intermediate monocyte: 4 nTPM
naive CD8 T-cell: 3.9 nTPM
NK-cell: 3.6 nTPM

Brain region

choroid plexus: 194 nTPM
basal ganglia: 50 nTPM
hippocampal formation: 42 nTPM
cerebral cortex: 42 nTPM
hypothalamus: 31 nTPM
cerebellum: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 1.61
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cholesterol binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

DEP domain
Winged helix-like DNA-binding domain superfamily
Winged helix DNA-binding domain superfamily
Regulators of mTOR signaling and Rac activation
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Membrane transport PIN-like
Integral membrane protein GPR155, DEP domain
Membrane transport protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR155 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KICSTOR

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR155 as an antibody target. Whether an autoantibody or antibody against GPR155 could matter depends on whether native GPR155 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR155 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPR155 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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