Seroatlas · Human Serome Atlas

KAT8

Histone acetyltransferase KAT8

Also known as: FLJ14040, hMOF, KAT8_HUMAN, MOF, MYST1, ZC2HC8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H7Z6
Gene
KAT8
Ensembl
ENSG00000103510
Chromosome
16
Canonical length
458 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q9H7Z6|KAT8
     1  MAAQGAAAAV AAGTSGVAGE GEPGPGENAA AEGTAPSPGR VSPPTPARGE PEVTVEIGET
    61  YLCRRPDSTW HSAEVIQSRV NDQEGREEFY VHYVGFNRRL DEWVDKNRLA LTKTVKDAVQ
   121  KNSEKYLSEL AEQPERKITR NQKRKHDEIN HVQKTYAEMD PTTAALEKEH EAITKVKYVD
   181  KIHIGNYEID AWYFSPFPED YGKQPKLWLC EYCLKYMKYE KSYRFHLGQC QWRQPPGKEI
   241  YRKSNISVYE VDGKDHKIYC QNLCLLAKLF LDHKTLYFDV EPFVFYILTE VDRQGAHIVG
   301  YFSKEKESPD GNNVACILTL PPYQRRGYGK FLIAFSYELS KLESTVGSPE KPLSDLGKLS
   361  YRSYWSWVLL EILRDFRGTL SIKDLSQMTS ITQNDIISTL QSLNMVKYWK GQHVICVTPK
   421  LVEEHLKSAQ YKKPPITVDS VCLKWAPPKH KQVKLSKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KAT8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
77 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 77 nTPM
  • ovary: 60 nTPM
  • skeletal muscle: 50 nTPM
  • tongue: 47 nTPM
  • epididymis: 44 nTPM
  • heart muscle: 41 nTPM

Single-cell type

  • late spermatids: 230 nCPM
  • epididymal principal cells: 209 nCPM
  • early spermatids: 166 nCPM
  • neutrophils: 136 nCPM
  • myonuclei: 83 nCPM
  • ovarian stromal cells: 69 nCPM

Immune cell

  • eosinophil: 30 nTPM
  • neutrophil: 29 nTPM
  • non-classical monocyte: 8.4 nTPM
  • basophil: 7.8 nTPM
  • classical monocyte: 7.4 nTPM
  • myeloid DC: 6.6 nTPM

Brain region

  • cerebellum: 53 nTPM
  • cerebral cortex: 39 nTPM
  • white matter: 37 nTPM
  • medulla oblongata: 36 nTPM
  • thalamus: 36 nTPM
  • midbrain: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KAT8.

Disease | AllUniProt

Conditions KAT8 is implicated in, by any mechanism.

  • Li-Ghorbani-Weisz-Hubshman syndrome (LIGOWS) MIM:618974

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 172 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.22
gnomAD missense Z
3.15
DepMap mean gene effect
-1.56
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KAT8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KAT8 as an antibody target. Whether an autoantibody or antibody against KAT8 could matter depends on whether native KAT8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KAT8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KAT8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KAT8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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