H1-0

Protein identityUniProt · HPA

UniProt accession

P07305

Gene

H1-0

Ensembl

ENSG00000189060

Chromosome

22

Canonical length

194 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies,Golgi apparatus,Actin filaments

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>P07305|H1-0
     1  MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI QKYIKSHYKV
    61  GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE PKKSVAFKKT KKEIKKVATP
   121  KKASKPKKAA SKAPTKKPKA TPVKKAKKKL AATPKKAKKP KTVKAKPVKA SKPKKAKPVK
   181  PKAKSSAKRA GKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H1-0 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.61

Highest tissue expression

668 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H1-0.

Disease | ImmuneIEDB

Conditions an epitope on H1-0 was assayed in.

• rheumatoid arthritis B cell
• systemic scleroderma B cell
• systemic lupus erythematosus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.9

gnomAD pLI

0.64

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chromosome condensation
• heterochromatin formation
• negative regulation of DNA recombination
• nucleosome assembly
• positive regulation of transcription regulatory region DNA binding

Molecular functions

• chromatin DNA binding
• double-stranded DNA binding
• minor groove of adenine-thymine-rich DNA binding
• nucleosomal DNA binding
• nucleosome binding
• RNA binding
• structural constituent of chromatin

Cellular components

• actin cytoskeleton
• chromatin
• euchromatin
• Golgi apparatus
• nuclear body
• nucleoplasm
• nucleosome
• nucleus
• transcription repressor complex

Protein domainsUniProt · Pfam · InterPro

• Linker histone H1/H5, domain H15
• Linker histone H1/H5
• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• linker histone H1 and H5 family

KeywordsUniProt

• Acetylation
• ADP-ribosylation
• Chromosome
• Citrullination
• DNA-binding
• Nucleus
• Phosphoprotein
• RNA editing

InteractionsUniProt · HPA

Protein binding partners of H1-0 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• H2AC14
• H2AC21
• H2BC21
• PARP1