Seroatlas · Human Serome Atlas

ERFL

ETS domain-containing transcription factor ERF-like

Also known as: ERFL_HUMAN, erfl1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1W2PQ73
Gene: ERFL
Ensembl: ENSG00000268041
Chromosome: 19
Canonical length: 354 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>A0A1W2PQ73|ERFL
     1  MDCSCVSDLL FAPPALPALW TPGFAFPDWA YKPESSPGSR QIQLWHFILE LLQKEEYQGV
    61  IAWQGDYGEF VIKDPDEVAR LWGIRKCKPH MNYDKLSRAL RYYYNKRILH KTKGKRFTYK
   121  FNFSKVVLVN YPLLDMAAAA TGSPLLLTPS PFGGAPGPDA PPLTPETLQT LFSAPRLGEP
   181  GARTPLFTSE TDKLRLDSPF PFLGSGATSY SKPPGLLGPY GRAFPEYPWN FNPYLTGPFP
   241  KLPPSLYPPH FYPNPLASSL GHLPSSGAGG GPTATPLLAS TGEGLGPERP SGLAAAPRLA
   301  LPGAGGPEAA LGGKEDSDSE LEITDVSGCS SDSEGDEGLP APPKAKAGKG GTGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERFL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

lymph node: 2.9 nTPM
spleen: 2.9 nTPM
small intestine: 2.6 nTPM
cerebellum: 2.1 nTPM
testis: 1.4 nTPM
appendix: 1.2 nTPM

Single-cell type

medullary thymic epithelial cells: 7.2 nCPM
thymocytes: 5.9 nCPM
epicardial cells: 4.5 nCPM
t-cells: 4.4 nCPM
retinal horizontal cells: 4 nCPM
hematopoietic stem cells: 3.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 4.7 nTPM
pons: 4.1 nTPM
basal ganglia: 4 nTPM
medulla oblongata: 3.7 nTPM
white matter: 3.1 nTPM
cerebellum: 2.5 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERFL as an antibody target. Whether an autoantibody or antibody against ERFL could matter depends on whether native ERFL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERFL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERFL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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