Seroatlas · Human Serome Atlas

FOXI3

Forkhead box protein I3

Also known as: FOXI3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MTJ6
Gene: FOXI3
Ensembl: ENSG00000214336
Chromosome: 2
Canonical length: 420 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in pharyngeal system development. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>A8MTJ6|FOXI3
     1  MALYCGDNFG VYSQPGLPPP AATAAAPGAP PAARAPYGLA DYAAPPAAAA NPYLWLNGPG
    61  VGGPPSAAAA AAAAYLGAPP PPPPPGAAAG PFLQPPPAAG TFGCSQRPFA QPAPAAPASP
   121  AAPAGPGELG WLSMASREDL MKMVRPPYSY SALIAMAIQS APERKLTLSH IYQFVADSFP
   181  FYQRSKAGWQ NSIRHNLSLN DCFKKVPRDE DDPGKGNYWT LDPNCEKMFD NGNFRRKRKR
   241  RSEASNGSTV AAGTSKSEEG LSSGLGSGVG GKPEEESPST LLRPSHSPEP PEGTKSTASS
   301  PGGPMLTSTP CLNTFFSSLS SLSVSSSVST QRALPGSRHL GIQGAQLPSS GVFSPTSISE
   361  ASADTLQLSN STSNSTGQRS SYYSPFPAST SGGQSSPFSS PFHNFSMVNS LIYPREGSEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXI3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 4.9 nTPM

Expression across tissuesHPA

Tissue

placenta: 4.9 nTPM
retina: 1.8 nTPM
testis: 0.4 nTPM
bone marrow: 0.1 nTPM
pancreas: 0.1 nTPM
parathyroid gland: 0.1 nTPM

Single-cell type

müller glia: 11 nCPM
cytotrophoblasts: 5.2 nCPM
migrating cytotrophoblasts: 3.1 nCPM
breast myoepithelial cells: 2.6 nCPM
syncytiotrophoblasts: 2.6 nCPM
undifferentiated spermatogonia: 0.9 nCPM

Immune cell

basophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.9 nTPM
cerebellum: 0.8 nTPM
choroid plexus: 0.8 nTPM
midbrain: 0.8 nTPM
basal ganglia: 0.7 nTPM
medulla oblongata: 0.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FOXI3.

Disease | AllUniProt

Conditions FOXI3 is implicated in, by any mechanism.

Craniofacial microsomia 2 (CFM2) MIM:620444

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 409 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXI3 as an antibody target. Whether an autoantibody or antibody against FOXI3 could matter depends on whether native FOXI3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXI3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXI3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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