Seroatlas · Human Serome Atlas

FOXP1

Forkhead box protein P1

Also known as: 12CC4, FOXP1_HUMAN, hFKH1B, HSPC215, QRF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H334
Gene: FOXP1
Ensembl: ENSG00000114861
Chromosome: 3
Canonical length: 677 aa
Protein class: Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

677 residues, UniProt reviewed canonical sequence.

>Q9H334|FOXP1
     1  MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD LAHAQQQQQQ
    61  ALQVARQLLL QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV
   121  LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ QEQLQLQLLQ QQHAGKQPKE QQQVATQQLA
   181  FQQQLLQMQQ LQQQHLLSLQ RQGLLTIQPG QPALPLQPLA QGMIPTELQQ LWKEVTSAHT
   241  AEETTGNNHS SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ LSVHTPKRES LSHEEHPHSH
   301  PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ CRVQMQVVQQ LELQLAKDKE
   361  RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP QSLPHTPTTP TAPLTPVTQG
   421  PSVITTTSMH TVGPIRRRYS DKYNVPISSA DIAQNQEFYK NAEVRPPFTY ASLIRQAILE
   481  SPEKQLTLNE IYNWFTRMFA YFRRNAATWK NAVRHNLSLH KCFVRVENVK GAVWTVDEVE
   541  FQKRRPQKIS GNPSLIKNMQ SSHAYCTPLN AALQASMAEN SIPLYTTASM GNPTLGNLAS
   601  AIREELNGAM EHTNSNESDS SPGRSPMQAV HPVHVKEEPL DPEEAEGPLS LVTTANHSPD
   661  FDHDRDYEDE PVNEDME

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 34 nTPM
blood vessel: 26 nTPM
colon: 25 nTPM
ovary: 23 nTPM
salivary gland: 23 nTPM
thymus: 21 nTPM

Single-cell type

renal collecting duct intercalated cells: 1,998 nCPM
distal convoluted tubule cells: 745 nCPM
renal connecting tubule cells: 719 nCPM
papillary tip epithelial cells: 625 nCPM
podocytes: 530 nCPM
loop of henle epithelial cells: 467 nCPM

Immune cell

memory B-cell: 32 nTPM
basophil: 22 nTPM
naive B-cell: 20 nTPM
naive CD4 T-cell: 17 nTPM
neutrophil: 14 nTPM
T-reg: 12 nTPM

Brain region

basal ganglia: 110 nTPM
cerebral cortex: 72 nTPM
choroid plexus: 57 nTPM
midbrain: 55 nTPM
white matter: 53 nTPM
thalamus: 47 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FOXP1.

Disease | AllUniProt

Conditions FOXP1 is implicated in, by any mechanism.

Intellectual developmental disorder with language impairment and with or without autistic features (IDDLA) MIM:613670

Disease | GeneticClinVar

201 pathogenic / likely-pathogenic of 1,101 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability-severe speech delay-mild dysmorphism syndrome
Inborn genetic diseases
Intellectual disability
INTELLECTUAL DEVELOPMENTAL DISORDER WITH LANGUAGE IMPAIRMENT AND AUTISTIC FEATURES
FOXP1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 2.28
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FOXP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXP1 as an antibody target. Whether an autoantibody or antibody against FOXP1 could matter depends on whether native FOXP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...