TFDP1
Transcription factor Dp-1
Also known as: DILC, Dp-1, DP1, DRTF1, TFDP1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q14186
- Gene
- TFDP1
- Ensembl
- ENSG00000198176
- Chromosome
- 13
- Canonical length
- 410 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nuclear membrane,Cytosol
OverviewNCBI Gene
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
Canonical amino-acid sequenceUniProt
410 residues, UniProt reviewed canonical sequence.
>Q14186|TFDP1
1 MAKDAGLIEA NGELKVFIDQ NLSPGKGVVS LVAVHPSTVN PLGKQLLPKT FGQSNVNIAQ
61 QVVIGTPQRP AASNTLVVGS PHTPSTHFAS QNQPSDSSPW SAGKRNRKGE KNGKGLRHFS
121 MKVCEKVQRK GTTSYNEVAD ELVAEFSAAD NHILPNESAY DQKNIRRRVY DALNVLMAMN
181 IISKEKKEIK WIGLPTNSAQ ECQNLEVERQ RRLERIKQKQ SQLQELILQQ IAFKNLVQRN
241 RHAEQQASRP PPPNSVIHLP FIIVNTSKKT VIDCSISNDK FEYLFNFDNT FEIHDDIEVL
301 KRMGMACGLE SGSCSAEDLK MARSLVPKAL EPYVTEMAQG TVGGVFITTA GSTSNGTRFS
361 ASDLTNGADG MLATSSNGSQ YSGSRVETPV SYVGEDDEED DDFNENDEDDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TFDP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 155 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 155 nTPM
- tonsil: 64 nTPM
- lymph node: 63 nTPM
- tongue: 55 nTPM
- skeletal muscle: 55 nTPM
- thymus: 50 nTPM
Single-cell type
- erythrocyte progenitors: 377 nCPM
- neutrophils: 349 nCPM
- neutrophil progenitors: 163 nCPM
- extravillous trophoblasts: 150 nCPM
- esophageal basal cells: 132 nCPM
- migrating cytotrophoblasts: 128 nCPM
Immune cell
- basophil: 32 nTPM
- naive CD4 T-cell: 6.3 nTPM
- myeloid DC: 5.9 nTPM
- non-classical monocyte: 5.6 nTPM
- T-reg: 5.4 nTPM
- eosinophil: 4.6 nTPM
Brain region
- choroid plexus: 43 nTPM
- medulla oblongata: 33 nTPM
- thalamus: 31 nTPM
- spinal cord: 31 nTPM
- pons: 28 nTPM
- white matter: 28 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.32
- gnomAD pLI
- 0.97
- gnomAD missense Z
- 2.28
- DepMap mean gene effect
- -0.45
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- anoikis
- epidermis development
- negative regulation of fat cell proliferation
- positive regulation of DNA-binding transcription factor activity
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of transcription by RNA polymerase II
- regulation of DNA biosynthetic process
- regulation of DNA-templated transcription
- regulation of transcription by RNA polymerase II
- transcription by RNA polymerase II
Molecular functions
- cis-regulatory region sequence-specific DNA binding
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription factor binding
- protein domain specific binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- E2F/DP family, winged-helix DNA-binding domain
- Transcription factor DP, C-terminal
- Transcription factor DP
- Winged helix-like DNA-binding domain superfamily
- Winged helix DNA-binding domain superfamily
- E2F-DP heterodimerization region
- Transcription factor DP, C-terminal domain superfamily
- E2F/DP family winged-helix DNA-binding domain
- Transcription factor DP
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TFDP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TFDP1 as an antibody target. Whether an autoantibody or antibody against TFDP1 could matter depends on whether native TFDP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TFDP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TFDP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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