Seroatlas · Human Serome Atlas

EIF3K

Eukaryotic translation initiation factor 3 subunit K

Also known as: ARG134, EIF3K_HUMAN, EIF3S12, HSPC029, M9, PLAC-24, PRO1474, PTD001

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBQ5
Gene
EIF3K
Ensembl
ENSG00000178982
Chromosome
19
Canonical length
218 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>Q9UBQ5|EIF3K
     1  MAMFEQMRAN VGKLLKGIDR YNPENLATLE RYVETQAKEN AYDLEANLAV LKLYQFNPAF
    61  FQTTVTAQIL LKALTNLPHT DFTLCKCMID QAHQEERPIR QILYLGDLLE TCHFQAFWQA
   121  LDENMDLLEG ITGFEDSVRK FICHVVGITY QHIDRWLLAE MLGDLSDSQL KVWMSKYGWS
   181  ADESGQIFIC SQEESIKPKN IVEKIDFDSV SSIMASSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3K can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
749 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 749 nTPM
  • heart muscle: 639 nTPM
  • tongue: 431 nTPM
  • kidney: 372 nTPM
  • skin: 316 nTPM
  • esophagus: 314 nTPM

Single-cell type

  • esophageal suprabasal cells: 1,087 nCPM
  • esophageal basal cells: 1,055 nCPM
  • esophageal apical cells: 774 nCPM
  • hofbauer cells: 773 nCPM
  • enterocytes: 739 nCPM
  • decidual stromal cells: 707 nCPM

Immune cell

  • total PBMC: 442 nTPM
  • myeloid DC: 360 nTPM
  • non-classical monocyte: 307 nTPM
  • intermediate monocyte: 298 nTPM
  • T-reg: 297 nTPM
  • classical monocyte: 269 nTPM

Brain region

  • choroid plexus: 84 nTPM
  • white matter: 67 nTPM
  • cerebellum: 66 nTPM
  • thalamus: 65 nTPM
  • medulla oblongata: 63 nTPM
  • spinal cord: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
0.76
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3K in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3K as an antibody target. Whether an autoantibody or antibody against EIF3K could matter depends on whether native EIF3K is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3K is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3K as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF3K. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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