ASMTL

Protein identityUniProt · HPA

UniProt accession

O95671

Gene

ASMTL

Ensembl

ENSG00000169093

Chromosome

X

Canonical length

621 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

621 residues, UniProt reviewed canonical sequence.

>O95671|ASMTL
     1  MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS FATPYGYAME
    61  TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK PVDKQDAYRM LSRLSGREHS
   121  VFTGVAIVHC SSKDHQLDTR VSEFYEETKV KFSELSEELL WEYVHSGEPM DKAGGYGIQA
   181  LGGMLVESVH GDFLNVVGFP LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD
   241  VEGGGSEPTQ RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
   301  LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK TEQGYSNTET
   361  ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN QHHRALGKKA EDLFQDAYYQ
   421  SPETRLRFMR AMHGMTKLTA CQVATAFNLS RFSSACDVGG CTGALARELA REYPRMQVTV
   481  FDLPDIIELA AHFQPPGPQA VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS
   541  RVAESCKPGA GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
   601  QVQVVHLGGV LDAILATKVA P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASMTL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

37 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1

gnomAD pLI

0

gnomAD missense Z

-0.61

OntologyGO

Biological processes

• methylation
• nucleotide metabolic process

Molecular functions

• nucleoside triphosphate diphosphatase activity
• O-methyltransferase activity
• protein dimerization activity
• UTP diphosphatase activity
• dTTP diphosphatase activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• O-methyltransferase, C-terminal domain
• Caffeic acid 3-O-methyltransferase-like, dimerisation domain
• O-methyltransferase-like
• Inosine triphosphate pyrophosphatase-like
• S-adenosyl-L-methionine-dependent methyltransferase superfamily
• Winged helix-like DNA-binding domain superfamily
• Winged helix DNA-binding domain superfamily
• O-methyltransferase domain
• O-methyltransferase dimerisation domain
• Nucleoside triphosphate pyrophosphatase Maf-like protein
• Maf-like protein

KeywordsUniProt

• Hydrolase
• Methyltransferase
• Nucleotide metabolism
• Phosphoprotein
• S-adenosyl-L-methionine
• Transferase

InteractionsUniProt · HPA

Protein binding partners of ASMTL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TDO2