FOXO3B
Forkhead box protein O3B
Also known as: FKHRL1P1, FXO3B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A2Z4LIS9
- Gene
- FOXO3B
- Ensembl
- ENSG00000240445
- Chromosome
- 17
- Canonical length
- 290 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrial matrix. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
290 residues, UniProt reviewed canonical sequence.
>A0A2Z4LIS9|FOXO3B
1 METDLAEMPE KGVLSSQDSP HFQEKSTEEG EVAALRLTAR SQAAAAAAAP GSRSLRGVHV
61 PPPLHPAPAR EESARTPAAA GRAAKMAEAP ASPAPLSPLE VELDPEFEPQ SRPRSCTWPL
121 QRPELQASPA KPSGETAADS MIPEEEDDED DEDGGGRAGS AMAIGGGGGS RTLVSGLLLE
181 DSVRVLAPGG QDPGSGPATA AGGLSGGTQA LLQPQQPLPP PQPGAAGGSG QPRKCSSRRN
241 AWGNLSYADL ITRAIESSPD RRLTLSQIYE WMVSCVPYFK DKGNSNSSAGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FOXO3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.68
- Highest tissue expression
- 4.4 nTPM
Expression across tissuesHPA
Tissue
- ovary: 4.4 nTPM
- endometrium: 3.3 nTPM
- thymus: 2.2 nTPM
- cerebral cortex: 2.1 nTPM
- cervix: 1.9 nTPM
- testis: 1.8 nTPM
Single-cell type
- megakaryocyte-erythroid progenitors: 0.4 nCPM
- peritubular myoid cells: 0.2 nCPM
- prostatic glandular cells: 0.2 nCPM
- alveolar cells type 1: 0.1 nCPM
- bergmann glia: 0.1 nCPM
- brain inhibitory neurons: 0.1 nCPM
Immune cell
- memory CD8 T-cell: 1.2 nTPM
- naive CD4 T-cell: 0.9 nTPM
- T-reg: 0.9 nTPM
- naive CD8 T-cell: 0.7 nTPM
- gdT-cell: 0.6 nTPM
- MAIT T-cell: 0.6 nTPM
Brain region
- white matter: 11 nTPM
- cerebellum: 9.9 nTPM
- basal ganglia: 8.3 nTPM
- cerebral cortex: 8.1 nTPM
- medulla oblongata: 8 nTPM
- thalamus: 7.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- DepMap mean gene effect
- -0.16
- DepMap dependency class
- selective
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FOXO3B as an antibody target. Whether an autoantibody or antibody against FOXO3B could matter depends on whether native FOXO3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FOXO3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FOXO3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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