Seroatlas · Human Serome Atlas

CUL4A

Cullin-4A

Also known as: CUL4A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13619
Gene
CUL4A
Ensembl
ENSG00000139842
Chromosome
13
Canonical length
759 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

759 residues, UniProt reviewed canonical sequence.

>Q13619|CUL4A
     1  MADEAPRKGS FSALVGRTNG LTKPAALAAA PAKPGGAGGS KKLVIKNFRD RPRLPDNYTQ
    61  DTWRKLHEAV RAVQSSTSIR YNLEELYQAV ENLCSHKVSP MLYKQLRQAC EDHVQAQILP
   121  FREDSLDSVL FLKKINTCWQ DHCRQMIMIR SIFLFLDRTY VLQNSTLPSI WDMGLELFRT
   181  HIISDKMVQS KTIDGILLLI ERERSGEAVD RSLLRSLLGM LSDLQVYKDS FELKFLEETN
   241  CLYAAEGQRL MQEREVPEYL NHVSKRLEEE GDRVITYLDH STQKPLIACV EKQLLGEHLT
   301  AILQKGLDHL LDENRVPDLA QMYQLFSRVR GGQQALLQHW SEYIKTFGTA IVINPEKDKD
   361  MVQDLLDFKD KVDHVIEVCF QKNERFVNLM KESFETFINK RPNKPAELIA KHVDSKLRAG
   421  NKEATDEELE RTLDKIMILF RFIHGKDVFE AFYKKDLAKR LLVGKSASVD AEKSMLSKLK
   481  HECGAAFTSK LEGMFKDMEL SKDIMVHFKQ HMQNQSDSGP IDLTVNILTM GYWPTYTPME
   541  VHLTPEMIKL QEVFKAFYLG KHSGRKLQWQ TTLGHAVLKA EFKEGKKEFQ VSLFQTLVLL
   601  MFNEGDGFSF EEIKMATGIE DSELRRTLQS LACGKARVLI KSPKGKEVED GDKFIFNGEF
   661  KHKLFRIKIN QIQMKETVEE QVSTTERVFQ DRQYQIDAAI VRIMKMRKTL GHNLLVSELY
   721  NQLKFPVKPG DLKKRIESLI DRDYMERDKD NPNQYHYVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CUL4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
161 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 161 nTPM
  • tongue: 117 nTPM
  • bone marrow: 60 nTPM
  • heart muscle: 59 nTPM
  • skin: 45 nTPM
  • testis: 44 nTPM

Single-cell type

  • cardiomyocytes: 238 nCPM
  • myonuclei: 230 nCPM
  • late spermatids: 214 nCPM
  • gastric progenitor cells: 138 nCPM
  • monocytes: 131 nCPM
  • suprabasal keratinocytes: 129 nCPM

Immune cell

  • memory CD8 T-cell: 31 nTPM
  • non-classical monocyte: 31 nTPM
  • intermediate monocyte: 29 nTPM
  • naive CD8 T-cell: 28 nTPM
  • gdT-cell: 28 nTPM
  • memory CD4 T-cell: 27 nTPM

Brain region

  • choroid plexus: 59 nTPM
  • medulla oblongata: 47 nTPM
  • white matter: 45 nTPM
  • midbrain: 41 nTPM
  • hypothalamus: 40 nTPM
  • pons: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.12
gnomAD pLI
1
gnomAD missense Z
2.81
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CUL4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CUL4A as an antibody target. Whether an autoantibody or antibody against CUL4A could matter depends on whether native CUL4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CUL4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CUL4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CUL4A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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